Three different questions wear the same word. Who furs their arteries, who has a heart attack early, and whose heart falls out of rhythm are separate problems with separate genetics — and this site keeps them on separate pages for that reason.
Why this topic Wearables now tell people about their own rhythm, and an irregular one is the commonest reason a healthy adult is suddenly a patient. Atrial fibrillation is also the place on this site where a single locus keeps reappearing — fifteen of our positions sit near PITX2, all for the same trait.
Source: Nielsen et al., Nature Genetics 2018 — biobank-driven genomic discovery in atrial fibrillation
2026-04-29 · Mass General Brigham Heart and Vascular Institute & Broad Institute of MIT and Harvard, published in JACC (245,394 All of Us participants; validated in a separate 53,306-person biobank cohort)
Two of the 8 conditions in this new clinical polygenic risk report are coronary artery disease and atrial fibrillation, both on this page: people in the top 10% of genetic risk were 3.7x more likely to develop coronary artery disease than those at average risk, in a score trained on 245,394 All of Us participants and validated in a separate 53,306-person biobank. The test is now clinically available through Mass General Brigham's Laboratory for Molecular Medicine and Broad Clinical Labs -- a risk score, not a diagnosis or treatment.
2025-10-20 · Zhang et al., Circulation 2025, PMID:41111418
'Asian Flush' Gene Variant Linked to Worse Heart Damage After a Heart Attack
A CityU Hong Kong team studied 177 Chinese patients with acute heart failure following a heart attack: carriers of the ALDH2 mutation behind the "Asian flush" alcohol reaction showed significantly more severe cardiac dysfunction, through a mechanism where the mutated ALDH2 protein loses its normal interaction with eIF3E, letting a cell-death process called ferroptosis run unchecked in heart muscle cells. An early-stage mechanistic finding, not an available treatment or diagnostic test -- see this site's rs671 page for the variant itself.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.
LPA
Parental lifespan (LPA, lipoprotein(a))
37 papers →LPA
Coronary heart disease
35 papers →ALDH2
Alcohol flush reaction
33 papers →MTHFR
Folate metabolism (MTHFR C677T)
32 papers →APOE
Lewy body disease
32 papers →PITX2
Atrial fibrillation/atrial flutter
26 papers →CYP2C19
CYP2C19 *2 — clopidogrel activation
21 papers →KCNN3
Atrial fibrillation
16 papers →APOA5
Triglyceride levels
16 papers →ADAMTS7
Coronary heart disease
15 papers →CYP3A5
CYP3A5 expression (*3 allele)
15 papers →LDLR
Myocardial infarction (early onset)
14 papers →NPPB
B-type natriuretic peptide levels
14 papers →SLCO1B1
Statin muscle-side-effect risk
14 papers →F5
Blood clotting risk (Factor V Leiden)
13 papers →ZNF259
Triglyceride levels
13 papers →MTHFR
Folate metabolism (MTHFR A1298C)
12 papers →CAV1
PR interval
12 papers →ACE
Angiotensin-converting enzyme activity
12 papers →VKORC1
Warfarin sensitivity
12 papers →TGFB1
Colorectal cancer
11 papers →ICAM1
Soluble ICAM-1
11 papers →CETP
HDL cholesterol
10 papers →CYP2C19
CYP2C19 *3 — clopidogrel activation
10 papers →ABO
Soluble E-selectin levels
10 papers →FTO
Menarche (age at onset)
10 papers →CXCL12
Myocardial infarction (early onset)
8 papers →AGER
Pulmonary function
8 papers →PHACTR1
Coronary heart disease
7 papers →PPAP2B
Coronary heart disease
7 papers →BDNF
Smoking behavior
7 papers →ADH1B
Alcohol metabolism speed
6 papers →PITX2
Atrial fibrillation
6 papers →HFE
Iron overload risk (HFE H63D)
6 papers →ABCA1
HDL cholesterol
6 papers →HDAC9
Stroke (ischemic)
6 papers →MIR146A
Systemic lupus erythematosus
6 papers →APOE
LDL cholesterol
6 papers →LDLR
Lipoprotein-associated phospholipase A2 activity and mass
6 papers →HCN4
Atrial fibrillation
6 papers →GCKR
Uric acid levels
6 papers →PROCR
Anticoagulant levels
6 papers →SYNPO2L
Atrial fibrillation
5 papers →SCARB1
Lipoprotein-associated phospholipase A2 activity and mass
5 papers →CYP2C19
CYP2C19 *17 — increased enzyme activity
5 papers →CELSR2
LDL cholesterol
5 papers →FADS1
Metabolite levels
5 papers →PITX2
Atrial fibrillation
5 papers →GOSR2
QRS duration
5 papers →TRIB1
Triglycerides
5 papers →APOB
Cholesterol, total
5 papers →DAB2IP
Abdominal aortic aneurysm
5 papers →C12orf67
PR interval
4 papers →SCN5A
PR interval
4 papers →CNNM2
Intracranial aneurysm
4 papers →NLRC5
HDL cholesterol
4 papers →ADIPOQ
Adiponectin levels
4 papers →ADAMTS7
Coronary artery disease
4 papers →KCNQ1
Type 2 diabetes
4 papers →KCNQ1
Type 2 diabetes
4 papers →GC
Vitamin D levels
4 papers →PCSK9
LDL cholesterol
4 papers →PITX2
Atrial fibrillation
4 papers →EDN1
Circulating vasoactive peptide levels
4 papers →SCN10A
PR interval
4 papers →ABO
ABO blood type
4 papers →LIPC
HDL cholesterol
3 papers →COBLL1
HDL cholesterol
3 papers →RASD1
Coronary heart disease
3 papers →ZNF648
HDL cholesterol
3 papers →CETP
HDL Cholesterol - Triglycerides (HDLC-TG)
3 papers →HLA-DQA2
Crohn's disease
3 papers →ICAM1
Soluble ICAM-1
3 papers →GIPR
Obesity
3 papers →HFE
Iron overload risk (hereditary hemochromatosis)
3 papers →SCN5A
Electrocardiographic conduction measures
3 papers →LPA
LDL cholesterol
3 papers →APOE
Alzheimer's disease (late onset)
3 papers →CCR5
HIV-1 resistance (CCR5-delta32)
3 papers →MYH6
Electrocardiographic traits
3 papers →MLXIPL
Triglycerides
3 papers →IL6R
C-reactive protein
3 papers →GALNT2
HDL cholesterol
3 papers →ABO
Hematological and biochemical traits
3 papers →MCM6 / LCT
Lactose tolerance
3 papers →KCNJ11
Type 2 diabetes
3 papers →WDR12
Myocardial infarction (early onset)
3 papers →TRIB1
Hypertriglyceridemia
3 papers →CELSR2
Lipoprotein-associated phospholipase A2 activity and mass
3 papers →CYP1A2
Caffeine metabolism
3 papers →PGPEP1
Growth differentiation factor-15 levels
3 papers →GIPR
Obesity
2 papers →CHRNA3
Smoking behavior
2 papers →C9orf3
Atrial fibrillation
2 papers →NT5C2
Systolic blood pressure
2 papers →LPL
Triglycerides
2 papers →CP
Serum ceruloplasmin levels
2 papers →GUCY1A3
Diastolic blood pressure
2 papers →TERC
Telomere length
2 papers →RIMS1
Schizophrenia
2 papers →FTO
Obesity
2 papers →LCAT
HDL cholesterol
2 papers →ATP2B1
Blood pressure
2 papers →FADS1
HDL cholesterol
2 papers →PITX2
Atrial fibrillation
2 papers →LPL
Metabolic syndrome
2 papers →IRS1
Triglycerides
2 papers →ICAM-1
Soluble levels of adhesion molecules
2 papers →CDKN1A
Atrial fibrillation
2 papers →NADSYN1
Vitamin D levels
2 papers →AGR3
Urinary albumin excretion
2 papers →CYP17A1
Colorectal cancer
2 papers →FUT2
Pediatric autoimmune diseases
2 papers →SCD
Metabolic traits
2 papers →UGT1A1
Bilirubin levels
2 papers →GLUT9
Urate levels
2 papers →HSPG2
Atrial fibrillation
2 papers →KCNJ2
Primary tooth development (number of teeth)
2 papers →CRP
C-reactive protein
2 papers →UGT1A1
Bilirubin levels
2 papers →IGF2AS
Type 1 diabetes
1 paper →CDKN2A
Breast cancer
1 paper →PRKAG2
Hemoglobin
1 paper →NCAN
LDL cholesterol
1 paper →INSIG2
LDL cholesterol
1 paper →LIPC
HDL cholesterol
1 paper →MTCH2
Body mass index
1 paper →LPA
HDL cholesterol
1 paper →ADIPOQ
Adiponectin levels
1 paper →SLCO1B1
Metabolite levels
1 paper →SCARB1
Vitamin E levels
1 paper →ACAD10
Esophageal cancer
1 paper →PTPN11
Hematological parameters
1 paper →IL23R
Crohn's disease
1 paper →ATM
Response to metformin in type 2 diabetes (glycemic)
1 paper →CALM3
Ulcerative colitis
1 paper →SLCO1A2
AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor
1 paper →CCL19
Rheumatoid arthritis
1 paper →ADCY5
Body mass index and fasting glucose (pairwise)
1 paper →C5orf23
Diastolic blood pressure
1 paper →CAV1/2
Atrial fibrillation
1 paper →AGPHD1
Local histogram emphysema pattern
1 paper →STAT4
Systemic lupus erythematosus
1 paper →near PLXDC2
Diabetic retinopathy
1 paper →MYL2
Alcohol consumption
1 paper →APOC3
Triglycerides
1 paper →SLC16A9
Uric acid levels
1 paper →GPRC5B
Obesity
1 paper →FN1
LDL cholesterol
1 paper →TTN
Atrial fibrillation
1 paper →IKZF2
Eosinophil count
1 paper →TERC
Telomere length
1 paper →MC4R
Waist circumference and related phenotypes
1 paper →IL1R1
Serum protein levels (sST2)
1 paper →ATP1B1
QT interval
1 paper →JAG1
Blood pressure
1 paper →KCNK9
Menarche (age at onset)
1 paper →ABCG2
Gout
1 paper →c10orf107
Diastolic blood pressure
1 paper →ADIPOQ
Adiponectin levels
1 paper →PHB
Diastolic blood pressure
1 paper →NCAN
LDL cholesterol
1 paper →TBL2
Triglycerides
1 paper →CASR
Calcium levels
1 paper →TAS2R38
Bitter taste perception (TAS2R38 position 262)
1 paper →ADIPOQ
Adiponectin levels
1 paper →FADS2
Daytime nap
1 paper →TNFRSF1A
Primary biliary cholangitis
1 paper →FGB
Fibrinogen
1 paper →BCHE
Cardiovascular disease risk factors
1 paper →ACTN3
Muscle fiber type ("sprinter gene")
1 paper →BCO2
Interleukin-18 levels
1 paper →CETP
Age-related macular degeneration
1 paper →GPR146
Cholesterol, total
1 paper →HPR
LDL cholesterol
1 paper →WNT8A
Atrial fibrillation
1 paper →C12orf51
Renal function-related traits (BUN)
1 paper →CYP7A1
Cholesterol, total
1 paper →EBF1
Longevity (90 years and older)
1 paper →FCER1A
IgE levels
1 paper →F11
Activated partial thromboplastin time
1 paper →MAPT
Atrial fibrillation
1 paper →ARID3B
Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio)
1 paper →PRDM16
QRS duration
1 paper →NKX2-5
PR interval
1 paper →XKR4
Serum thyroid-stimulating hormone levels
1 paper →LEF1
Metabolic traits
1 paper →RABEP2
Inflammatory bowel disease
1 paper →ATP2B1
Hypertension
1 paper →EHBP1
LDL cholesterol
1 paper →FTH1
Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
1 paper →F12
Circulating vasoactive peptide levels
1 paper →TERT
Lung adenocarcinoma
1 paper →DARC / ACKR1
Duffy blood group (malaria resistance)
1 paper →LINC01426
Atrial fibrillation
1 paper →KIAA0350
Type 1 diabetes
1 paper →KCNH2
QT interval
1 paper →HLA region
Systemic lupus erythematosus
1 paper →POLB
Plasma plasminogen activator levels
1 paper →SLC18A1
Triglycerides
1 paper →MTSS1
Atrial fibrillation
1 paper →IDOL
LDL cholesterol
1 paper →CYP17A1
Systolic blood pressure
1 paper →INSR
Thyroid hormone levels
1 paper →GATA2
Eosinophil count
1 paper →ABO
Soluble ICAM-1
1 paper →G6PC2
Fasting plasma glucose
1 paper →DMRTA2
Atrial fibrillation
1 paper →IL12A
Systemic lupus erythematosus
1 paper →PRRX1
Prevalent atrial fibrillation
1 paper →SELP
Activated partial thromboplastin time
1 paper →AR
Male pattern baldness tendency
1 paper →BCHE
Aspirin hydrolysis (plasma)
1 paper →MSL2L1
Triglycerides
1 paper →C17orf71
Circulating myeloperoxidase levels (plasma)
1 paper →QKI
Incident myocardial infarction
1 paper →AHR
Coffee consumption
1 paper →near POU5F1B
Prostate cancer
1 paper →ANGPTL4
HDL cholesterol
1 paper →DOCK6
HDL cholesterol
1 paper →SCGN
Uric acid levels
1 paper →IRS1
Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI)
1 paper →GNB4
Atrial fibrillation
1 paper →GCKR
Crohn's disease
1 paper →TCF7L2
Type 2 diabetes
1 paper →LGR5
Type 2 diabetes
1 paper →CFH
Circulating myeloperoxidase levels (serum)
1 paper →IL29
Chronic hepatitis C infection
1 paper →JAZF1
Type 2 diabetes
1 paper →STXBP5
Plasma plasminogen activator levels
1 paper →Europe PMC, title and abstract only, searched for “coronary artery disease”, “myocardial infarction”, “atrial fibrillation”, “heart failure” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Heart and circulation. MyGeneLog™. https://www.mygenelog.com/topics/heart
Heart and circulation is this site's topic page bringing together three separate questions that share one word: furred arteries, early heart attacks, and hearts that fall out of rhythm — each a separate problem with separate genetics, kept on its own condition page.
No — it depends which heart question the variant belongs to. Furred arteries, an early heart attack and a heart that falls out of rhythm are separate problems with separate genetics, so a variant here ties to just one of them, not to "heart disease" as a whole.
Because "heart" is the single word people search. This topic pools co-mentions across coronary artery disease, heart attack, atrial fibrillation and heart failure under that word, while the condition pages behind it keep each one's genetics apart.
Because fifteen of its published positions cluster near a single gene, PITX2 — an unusually concentrated repeat. It is still one locus among many known contributors to AFib risk, and a wearable's irregular-rhythm alert has plenty of non-genetic causes it cannot tell apart.
Europe PMC is searched for coronary artery disease, myocardial infarction, atrial fibrillation or heart failure appearing in a paper's title or abstract alongside a published rsID — a co-mention, not a cause, recounted every month.