Three different questions wear the same word. Who furs their arteries, who has a heart attack early, and whose heart falls out of rhythm are separate problems with separate genetics — and this site keeps them on separate pages for that reason.
Why this topic Wearables now tell people about their own rhythm, and an irregular one is the commonest reason a healthy adult is suddenly a patient. Atrial fibrillation is also the place on this site where a single locus keeps reappearing — fifteen of our positions sit near PITX2, all for the same trait.
Source: Nielsen et al., Nature Genetics 2018 — biobank-driven genomic discovery in atrial fibrillation
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.
LPA
Parental lifespan (LPA, lipoprotein(a))
37 papers →LPA
Coronary heart disease
35 papers →ALDH2
Alcohol flush reaction
33 papers →MTHFR
Folate metabolism (MTHFR C677T)
32 papers →APOE
Lewy body disease
32 papers →PITX2
Atrial fibrillation/atrial flutter
26 papers →CYP2C19
CYP2C19 *2 — clopidogrel activation
21 papers →KCNN3
Atrial fibrillation
16 papers →APOA5
Triglyceride levels
16 papers →ADAMTS7
Coronary heart disease
15 papers →CYP3A5
CYP3A5 expression (*3 allele)
15 papers →LDLR
Myocardial infarction (early onset)
14 papers →NPPB
B-type natriuretic peptide levels
14 papers →SLCO1B1
Statin muscle-side-effect risk
14 papers →F5
Blood clotting risk (Factor V Leiden)
13 papers →ZNF259
Triglyceride levels
13 papers →MTHFR
Folate metabolism (MTHFR A1298C)
12 papers →CAV1
PR interval
12 papers →ACE
Angiotensin-converting enzyme activity
12 papers →VKORC1
Warfarin sensitivity
12 papers →TGFB1
Colorectal cancer
11 papers →ICAM1
Soluble ICAM-1
11 papers →CETP
HDL cholesterol
10 papers →CYP2C19
CYP2C19 *3 — clopidogrel activation
10 papers →ABO
Soluble E-selectin levels
10 papers →FTO
Menarche (age at onset)
10 papers →CXCL12
Myocardial infarction (early onset)
8 papers →AGER
Pulmonary function
8 papers →PHACTR1
Coronary heart disease
7 papers →PPAP2B
Coronary heart disease
7 papers →BDNF
Smoking behavior
7 papers →ADH1B
Alcohol metabolism speed
6 papers →PITX2
Atrial fibrillation
6 papers →HFE
Iron overload risk (HFE H63D)
6 papers →ABCA1
HDL cholesterol
6 papers →HDAC9
Stroke (ischemic)
6 papers →MIR146A
Systemic lupus erythematosus
6 papers →APOE
LDL cholesterol
6 papers →LDLR
Lipoprotein-associated phospholipase A2 activity and mass
6 papers →HCN4
Atrial fibrillation
6 papers →GCKR
Uric acid levels
6 papers →PROCR
Anticoagulant levels
6 papers →SYNPO2L
Atrial fibrillation
5 papers →SCARB1
Lipoprotein-associated phospholipase A2 activity and mass
5 papers →CYP2C19
CYP2C19 *17 — increased enzyme activity
5 papers →CELSR2
LDL cholesterol
5 papers →FADS1
Metabolite levels
5 papers →PITX2
Atrial fibrillation
5 papers →GOSR2
QRS duration
5 papers →TRIB1
Triglycerides
5 papers →APOB
Cholesterol, total
5 papers →DAB2IP
Abdominal aortic aneurysm
5 papers →C12orf67
PR interval
4 papers →SCN5A
PR interval
4 papers →CNNM2
Intracranial aneurysm
4 papers →NLRC5
HDL cholesterol
4 papers →ADIPOQ
Adiponectin levels
4 papers →ADAMTS7
Coronary artery disease
4 papers →KCNQ1
Type 2 diabetes
4 papers →KCNQ1
Type 2 diabetes
4 papers →GC
Vitamin D levels
4 papers →PCSK9
LDL cholesterol
4 papers →PITX2
Atrial fibrillation
4 papers →EDN1
Circulating vasoactive peptide levels
4 papers →SCN10A
PR interval
4 papers →ABO
ABO blood type
4 papers →LIPC
HDL cholesterol
3 papers →COBLL1
HDL cholesterol
3 papers →RASD1
Coronary heart disease
3 papers →ZNF648
HDL cholesterol
3 papers →CETP
HDL Cholesterol - Triglycerides (HDLC-TG)
3 papers →HLA-DQA2
Crohn's disease
3 papers →ICAM1
Soluble ICAM-1
3 papers →GIPR
Obesity
3 papers →HFE
Iron overload risk (hereditary hemochromatosis)
3 papers →SCN5A
Electrocardiographic conduction measures
3 papers →LPA
LDL cholesterol
3 papers →APOE
Alzheimer's disease (late onset)
3 papers →CCR5
HIV-1 resistance (CCR5-delta32)
3 papers →MYH6
Electrocardiographic traits
3 papers →MLXIPL
Triglycerides
3 papers →IL6R
C-reactive protein
3 papers →GALNT2
HDL cholesterol
3 papers →ABO
Hematological and biochemical traits
3 papers →MCM6 / LCT
Lactose tolerance
3 papers →KCNJ11
Type 2 diabetes
3 papers →WDR12
Myocardial infarction (early onset)
3 papers →TRIB1
Hypertriglyceridemia
3 papers →CELSR2
Lipoprotein-associated phospholipase A2 activity and mass
3 papers →CYP1A2
Caffeine metabolism
3 papers →PGPEP1
Growth differentiation factor-15 levels
3 papers →GIPR
Obesity
2 papers →CHRNA3
Smoking behavior
2 papers →C9orf3
Atrial fibrillation
2 papers →NT5C2
Systolic blood pressure
2 papers →LPL
Triglycerides
2 papers →CP
Serum ceruloplasmin levels
2 papers →GUCY1A3
Diastolic blood pressure
2 papers →TERC
Telomere length
2 papers →RIMS1
Schizophrenia
2 papers →FTO
Obesity
2 papers →LCAT
HDL cholesterol
2 papers →ATP2B1
Blood pressure
2 papers →FADS1
HDL cholesterol
2 papers →PITX2
Atrial fibrillation
2 papers →LPL
Metabolic syndrome
2 papers →IRS1
Triglycerides
2 papers →ICAM-1
Soluble levels of adhesion molecules
2 papers →CDKN1A
Atrial fibrillation
2 papers →NADSYN1
Vitamin D levels
2 papers →AGR3
Urinary albumin excretion
2 papers →CYP17A1
Colorectal cancer
2 papers →FUT2
Pediatric autoimmune diseases
2 papers →SCD
Metabolic traits
2 papers →UGT1A1
Bilirubin levels
2 papers →GLUT9
Urate levels
2 papers →HSPG2
Atrial fibrillation
2 papers →KCNJ2
Primary tooth development (number of teeth)
2 papers →CRP
C-reactive protein
2 papers →UGT1A1
Bilirubin levels
2 papers →IGF2AS
Type 1 diabetes
1 paper →CDKN2A
Breast cancer
1 paper →PRKAG2
Hemoglobin
1 paper →NCAN
LDL cholesterol
1 paper →INSIG2
LDL cholesterol
1 paper →LIPC
HDL cholesterol
1 paper →MTCH2
Body mass index
1 paper →LPA
HDL cholesterol
1 paper →ADIPOQ
Adiponectin levels
1 paper →SLCO1B1
Metabolite levels
1 paper →SCARB1
Vitamin E levels
1 paper →ACAD10
Esophageal cancer
1 paper →PTPN11
Hematological parameters
1 paper →IL23R
Crohn's disease
1 paper →ATM
Response to metformin in type 2 diabetes (glycemic)
1 paper →CALM3
Ulcerative colitis
1 paper →SLCO1A2
AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor
1 paper →CCL19
Rheumatoid arthritis
1 paper →ADCY5
Body mass index and fasting glucose (pairwise)
1 paper →C5orf23
Diastolic blood pressure
1 paper →CAV1/2
Atrial fibrillation
1 paper →AGPHD1
Local histogram emphysema pattern
1 paper →STAT4
Systemic lupus erythematosus
1 paper →near PLXDC2
Diabetic retinopathy
1 paper →MYL2
Alcohol consumption
1 paper →APOC3
Triglycerides
1 paper →SLC16A9
Uric acid levels
1 paper →GPRC5B
Obesity
1 paper →FN1
LDL cholesterol
1 paper →TTN
Atrial fibrillation
1 paper →IKZF2
Eosinophil count
1 paper →TERC
Telomere length
1 paper →MC4R
Waist circumference and related phenotypes
1 paper →IL1R1
Serum protein levels (sST2)
1 paper →ATP1B1
QT interval
1 paper →JAG1
Blood pressure
1 paper →KCNK9
Menarche (age at onset)
1 paper →ABCG2
Gout
1 paper →c10orf107
Diastolic blood pressure
1 paper →ADIPOQ
Adiponectin levels
1 paper →PHB
Diastolic blood pressure
1 paper →NCAN
LDL cholesterol
1 paper →TBL2
Triglycerides
1 paper →CASR
Calcium levels
1 paper →TAS2R38
Bitter taste perception (TAS2R38 position 262)
1 paper →ADIPOQ
Adiponectin levels
1 paper →FADS2
Daytime nap
1 paper →TNFRSF1A
Primary biliary cholangitis
1 paper →FGB
Fibrinogen
1 paper →BCHE
Cardiovascular disease risk factors
1 paper →ACTN3
Muscle fiber type ("sprinter gene")
1 paper →BCO2
Interleukin-18 levels
1 paper →CETP
Age-related macular degeneration
1 paper →GPR146
Cholesterol, total
1 paper →HPR
LDL cholesterol
1 paper →WNT8A
Atrial fibrillation
1 paper →C12orf51
Renal function-related traits (BUN)
1 paper →CYP7A1
Cholesterol, total
1 paper →EBF1
Longevity (90 years and older)
1 paper →FCER1A
IgE levels
1 paper →F11
Activated partial thromboplastin time
1 paper →MAPT
Atrial fibrillation
1 paper →ARID3B
Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio)
1 paper →PRDM16
QRS duration
1 paper →NKX2-5
PR interval
1 paper →XKR4
Serum thyroid-stimulating hormone levels
1 paper →LEF1
Metabolic traits
1 paper →RABEP2
Inflammatory bowel disease
1 paper →ATP2B1
Hypertension
1 paper →EHBP1
LDL cholesterol
1 paper →FTH1
Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
1 paper →F12
Circulating vasoactive peptide levels
1 paper →TERT
Lung adenocarcinoma
1 paper →DARC / ACKR1
Duffy blood group (malaria resistance)
1 paper →LINC01426
Atrial fibrillation
1 paper →KIAA0350
Type 1 diabetes
1 paper →KCNH2
QT interval
1 paper →HLA region
Systemic lupus erythematosus
1 paper →POLB
Plasma plasminogen activator levels
1 paper →SLC18A1
Triglycerides
1 paper →MTSS1
Atrial fibrillation
1 paper →IDOL
LDL cholesterol
1 paper →CYP17A1
Systolic blood pressure
1 paper →INSR
Thyroid hormone levels
1 paper →GATA2
Eosinophil count
1 paper →ABO
Soluble ICAM-1
1 paper →G6PC2
Fasting plasma glucose
1 paper →DMRTA2
Atrial fibrillation
1 paper →IL12A
Systemic lupus erythematosus
1 paper →PRRX1
Prevalent atrial fibrillation
1 paper →SELP
Activated partial thromboplastin time
1 paper →AR
Male pattern baldness tendency
1 paper →BCHE
Aspirin hydrolysis (plasma)
1 paper →MSL2L1
Triglycerides
1 paper →C17orf71
Circulating myeloperoxidase levels (plasma)
1 paper →QKI
Incident myocardial infarction
1 paper →AHR
Coffee consumption
1 paper →near POU5F1B
Prostate cancer
1 paper →ANGPTL4
HDL cholesterol
1 paper →DOCK6
HDL cholesterol
1 paper →SCGN
Uric acid levels
1 paper →IRS1
Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI)
1 paper →GNB4
Atrial fibrillation
1 paper →GCKR
Crohn's disease
1 paper →TCF7L2
Type 2 diabetes
1 paper →LGR5
Type 2 diabetes
1 paper →CFH
Circulating myeloperoxidase levels (serum)
1 paper →IL29
Chronic hepatitis C infection
1 paper →JAZF1
Type 2 diabetes
1 paper →STXBP5
Plasma plasminogen activator levels
1 paper →Europe PMC, title and abstract only, searched for “coronary artery disease”, “myocardial infarction”, “atrial fibrillation”, “heart failure” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.