9 86116376222443Reads by AI crawlersClaude1ChatGPT16Google · Gemini3Perplexity7Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)4ByteDance (Doubao)4Others43Total86Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
ClassificationConflicting classifications of pathogenicity; other for Hemochromatosis type 1, Hereditary hemochromatosis, Cystic fibrosis, Bronze diabetes, Cardiomyopathy and 2 more; criteria provided, conflicting classifications (1 of 4 stars, 59 submitters), last evaluated 2026-08-06.
ClinVar record 10NM_000410.4(HFE):c.187C>G (p.His63Asp)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the H63D variant. Published research associates this genotype with mildly elevated iron-overload risk on its own — substantially less than two copies of C282Y (rs1800562), but still worth knowing, especially alongside that result.
G/COne copy of the H63D variant. On its own, published research associates this genotype with minimal added iron-overload risk — but combined with a C282Y variant (see rs1800562) on the other gene copy, risk is meaningfully elevated.
G/GNo copies of the H63D variant. Published research does not associate this genotype with elevated hereditary hemochromatosis risk from this variant.
This variant is usually interpreted together with C282Y (rs1800562) — check that result too. If you carry either variant, a ferritin/iron panel blood test is a reasonable conversation to have with a doctor.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs1799945
What is rs1799945?
rs1799945 is a single position in the genome, in or near the HFE gene. Published research associates it with iron overload risk (hfe h63d). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1799945 linked to?
On MyGeneLog this position is linked to Hereditary Hemochromatosis (HFE). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs1799945?
Subjects that appear in the title or abstract of the same papers as this rsID include running and endurance (6 papers), heart and circulation (6 papers), exercise and muscle (5 papers), blood sugar and insulin (3 papers), brain and memory (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs1799945 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1799945 come from?
Feder et al. 1996, Nature Genetics — a novel MHC class I-like gene (HFE) mutated in patients with hereditary haemochromatosis. PMID 8696333. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
9 86116376222443Reads by AI crawlersClaude1ChatGPT16Google · Gemini3Perplexity7Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)4ByteDance (Doubao)4Others43Total86Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Iron overload risk (HFE H63D) (rs1799945). MyGeneLog™. https://www.mygenelog.com/variants/rs1799945