2 6124649222129Reads by AI crawlersClaude2ChatGPT4Google · Gemini6Perplexity4Meta AI9Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others29Total61Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
ClassificationBenign for LIPOPROTEIN(a) POLYMORPHISM; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2020-08-07.
ClinVar record 225938NM_005577.4(LPA):c.3947+467T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies. Still a shift in an average rather than a fact about a life. The reason to record it is what it points at biologically, not what it predicts.
G/AOne copy of the associated allele. The associated allele is uncommon; most people carry none. What was measured is a difference in average parental lifespan across half a million families — months, not years, and invisible in any one family.
G/GNeither copy carries the associated allele. LPA makes apolipoprotein(a), the protein that turns an LDL particle into lipoprotein(a) — a cardiovascular risk factor that is largely inherited and barely moved by diet. On its own this tells one person almost nothing: the effect is a small shift in a population average, and how long anyone lives is mostly not genetic at all.
This is an association with how long a population lives, not a prediction about one person. Nothing here is used clinically, nothing here is a reason to take anything, and no genotype at this position changes what anyone should do.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs10455872
What is rs10455872?
rs10455872 is a single position in the genome, in or near the LPA gene. Published research associates it with parental lifespan (lpa, lipoprotein(a)). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10455872 linked to?
On MyGeneLog this position is linked to Human Lifespan and Longevity, Lipoprotein(a) Levels. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs10455872?
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (37 papers), cholesterol and blood fats (9 papers), blood sugar and insulin (5 papers), kidneys (2 papers), exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs10455872 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10455872 come from?
Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 9e-25. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 6124649222129Reads by AI crawlersClaude2ChatGPT4Google · Gemini6Perplexity4Meta AI9Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others29Total61Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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