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Parental lifespan (LPA, lipoprotein(a))

LPA · rs10455872

Where this position leads

Condition: Human Lifespan and Longevity

rs10455872 Condition: Human Lifespan and Longevity Human Lifespan and Longevity Condition rs10455872 rs10455872 LPA

What each result means

A/A Two copies. Still a shift in an average rather than a fact about a life. The reason to record it is what it points at biologically, not what it predicts.
G/A One copy of the associated allele. The associated allele is uncommon; most people carry none. What was measured is a difference in average parental lifespan across half a million families — months, not years, and invisible in any one family.
G/G Neither copy carries the associated allele. LPA makes apolipoprotein(a), the protein that turns an LDL particle into lipoprotein(a) — a cardiovascular risk factor that is largely inherited and barely moved by diet. On its own this tells one person almost nothing: the effect is a small shift in a population average, and how long anyone lives is mostly not genetic at all.
This is an association with how long a population lives, not a prediction about one person. Nothing here is used clinically, nothing here is a reason to take anything, and no genotype at this position changes what anyone should do.

Source: Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 9e-25.

What people read about alongside this

Exercise and muscle1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10455872

What is rs10455872?

rs10455872 is a single position in the genome, in or near the LPA gene. Published research associates it with parental lifespan (lpa, lipoprotein(a)). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10455872 linked to?

On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10455872?

Subjects that appear in the title or abstract of the same papers as this rsID include exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10455872 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10455872 come from?

Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 9e-25. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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