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Sensitive

Pediatric autoimmune diseases

FUT2 · rs602662

Where this position leads

Condition: Ulcerative Colitis

Supplement: Vitamin B12

rs602662 Condition: Ulcerative Colitis Ulcerative Colitis Condition Supplement: Vitamin B12 Vitamin B12 Supplement Topic: Vitamins and nutrient levels Vitamins and nutrient levels Topic rs602662 rs602662 FUT2

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 97 European ancestry thyroiditis cases, 107 European ancestry ankylosing spondylitis cases, 100 European ancestry psoriasis cases, 173 European ancestry celiac disease cases, 254 European ancestry systemic lupus erythematosus cases, 308 European ancestry common variable inmunodeficiency cases, 865 European ancestry ulcerative colitis cases, 1,086 European ancestry Type 1 diabetes cases, 1,123 European ancestry juvenile idiopathic arthritis cases, 1,922 European ancestry Crohn's disease cases, 10,718 European ancestry controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 5 × 10−8.

How common The G allele had a frequency of about 49% in the people studied.

Where it sits Chromosome 19, band 19q13.33 — a missense change in FUT2.

What ClinVar records

Classification confers sensitivity; other for Familial Otitis Media, Levothyroxine response; no assertion criteria provided (0 of 4 stars, 2 submitters). ClinVar record 996599 NM_000511.6(FUT2):c.772G>A (p.Gly258Ser)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A No copy of the version the research linked to Pediatric autoimmune diseases. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Pediatric autoimmune diseases. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Pediatric autoimmune diseases. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
Li YR, Li J, Zhao SD, Bradfield JP, Mentch FD, Maggadottir SM, Hou C, Abrams DJ, Chang D, Gao F, Guo Y, Wei Z
and 54 more — show all
Connolly JJ, Cardinale CJ, Bakay M, Glessner JT, Li D, Kao C, Thomas KA, Qiu H, Chiavacci RM, Kim CE, Wang F, Snyder J, Richie MD, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Russell RK, Wilson DC, Silverberg MS, Annese V, Lie BA, Punaro M, Dubinsky MC, Monos DS, Strisciuglio C, Staiano A, Miele E, Kugathasan S, Ellis JA, Munro JE, Sullivan KE, Wise CA, Chapel H, Cunningham-Rundles C, Grant SF, Orange JS, Sleiman PM, Behrens EM, Griffiths AM, Satsangi J, Finkel TH, Keinan A, Prak ET, Polychronakos C, Baldassano RN, Li H, Keating BJ, Hakonarson H
Nature medicine · 2015 · PMID 26301688

What people read about alongside this

Vitamins and nutrient levels3 Heart and circulation2 Blood sugar and insulin1 Cholesterol and blood fats1 Longevity and ageing1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs602662

What is rs602662?

rs602662 is a single position in the genome, in or near the FUT2 gene. Published research associates it with pediatric autoimmune diseases. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs602662 linked to?

On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs602662?

Subjects that appear in the title or abstract of the same papers as this rsID include vitamins and nutrient levels (3 papers), heart and circulation (2 papers), blood sugar and insulin (1 papers), cholesterol and blood fats (1 papers), longevity and ageing (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs602662 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs602662 come from?

GWAS Catalog, Nat Med 2015, PMID:26301688. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Pediatric autoimmune diseases (rs602662). MyGeneLog™. https://www.mygenelog.com/variants/rs602662

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