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Response to metformin in type 2 diabetes (glycemic)

ATM · rs11212617

Where this position leads

Condition: Type 2 Diabetes

Drug: Metformin

rs11212617 Condition: Type 2 Diabetes Type 2 Diabetes Condition Drug: Metformin Metformin Drug Topic: Blood sugar and insulin Blood sugar and insulin Topic rs11212617 rs11212617 ATM

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 1,024 European ancestry cases; replicated in 2,896 European ancestry cases.

The effect Each copy of the C allele carried 1.35 times the odds of Response to metformin in type 2 diabetes (glycemic) (95% confidence interval 1.22-1.49); p = 3 × 10−9.

How common The C allele had a frequency of about 44% in the people studied.

Where it sits Chromosome 11, band 11q22.3 — in an intron of C11orf65.

What each result means

A/A No copy of the version the research linked to Response to metformin in type 2 diabetes (glycemic). This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Response to metformin in type 2 diabetes (glycemic). That is a smaller link than two copies.
C/C Two copies of the version the research linked to Response to metformin in type 2 diabetes (glycemic). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, Hawley SA, Donnelly LA, Schofield C, Groves CJ, Burch L, Carr F
and 38 more — show all
Strange A, Freeman C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Gray E, Hunt S, Jankowski J, Langford C, Markus HS, Mathew CG, Plomin R, Rautanen A, Sawcer SJ, Samani NJ, Trembath R, Viswanathan AC, Wood NW, Harries LW, Hattersley AT, Doney AS, Colhoun H, Morris AD, Sutherland C, Hardie DG, Peltonen L, McCarthy MI, Holman RR, Palmer CN, Donnelly P, Pearson ER
GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group · Wellcome Trust Case Control Consortium 2 · MAGIC investigators
Nature genetics · 2011 · PMID 21186350 · open access

What people read about alongside this

Blood sugar and insulin18 Heart and circulation1 Infection and immunity1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs11212617

What is rs11212617?

rs11212617 is a single position in the genome, in or near the ATM gene. Published research associates it with response to metformin in type 2 diabetes (glycemic). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11212617 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does rs11212617 affect how medicines work?

ATM carries pharmacogenomic findings for Metformin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs11212617?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (18 papers), heart and circulation (1 papers), infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs11212617 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11212617 come from?

GWAS Catalog, Nat Genet 2010, PMID:21186350. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Response to metformin in type 2 diabetes (glycemic) (rs11212617). MyGeneLog™. https://www.mygenelog.com/variants/rs11212617

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