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Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 8,589 European ancestry individuals; replicated in 12,981 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 3.32 mg/dl higher; p = 3 × 10−9.
How common The G allele had a frequency of about 89% in the people studied.
Where it sits Chromosome 19, band 19p13.11 — between genes, 1 kb from CILP2.
What each result means
G/GTwo copies of the version the research linked to LDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to LDL cholesterol. That is a smaller link than two copies.
T/TNo copy of the version the research linked to LDL cholesterol. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs16996148
What is rs16996148?
rs16996148 is a single position in the genome, in or near the NCAN gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs16996148 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs16996148?
Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (5 papers), heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs16996148 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs16996148 come from?
GWAS Catalog, Nat Genet 2008, PMID:18193043. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 5562425122130Reads by AI crawlersClaude6ChatGPT2Google · Gemini4Perplexity2Meta AI5Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others30Total55Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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