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Atrial fibrillation

PITX2 · rs3853445

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 8,180 Japanese ancestry cases, 28,612 Japanese ancestry controls; replicated in 3,120 Japanese ancestry cases, 125,064 Japanese ancestry controls, 15,993 European ancestry cases, 113,719 European ancestry controls.

The effect Each copy of the T allele carried 1.33 times the odds of Atrial fibrillation (95% confidence interval 1.271-1.391); p = 2 × 10⁻³⁴.

How common The T allele had a frequency of about 67% in the people studied.

Where it sits Chromosome 4, band 4q25 — between genes, 20.3 kb from MIR297.

What each result means

C/C No copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT, Ogishima S, Yamamoto M, Satoh M, Sasaki M, Yamaji T, Iwasaki M

and 10 more — show all

Tsugane S, Tanaka K, Naito M, Wakai K, Tanaka H, Furukawa T, Kubo M, Ito K, Kamatani Y, Tanaka T

AFGen Consortium

Nature genetics · 2017 · PMID 28416822

What people read about alongside this

Heart and circulation4

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs3853445

What is rs3853445?

rs3853445 is a single position in the genome, in or near the PITX2 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3853445 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs3853445?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (4 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs3853445 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3853445 come from?

GWAS Catalog, Nat Genet 2017, PMID:28416822. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (rs3853445). MyGeneLog™. https://www.mygenelog.com/variants/rs3853445

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