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Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 4,549 European ancestry cases, 5,579 European ancestry controls; replicated in 24,194 European ancestry cases, 55,598 European ancestry controls.
The effect
Each copy of the C allele carried 1.09 times the odds of Type 2 diabetes (95% confidence interval 1.06-1.12); p = 1 × 10−9.
How common The C allele had a frequency of about 27% in the people studied.
Where it sits Chromosome 12, band 12q21.1 — inside TSPAN8.
What each result means
C/CTwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs7961581
What is rs7961581?
rs7961581 is a single position in the genome, in or near the LGR5 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7961581 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs7961581?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (15 papers), heart and circulation (1 papers), brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs7961581 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7961581 come from?
GWAS Catalog, Nat Genet 2008, PMID:18372903. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 5432536121229Reads by AI crawlersClaude3ChatGPT2Google · Gemini5Perplexity3Meta AI6Microsoft · Copilot1Amazon2Apple1China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others29Total54Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs7961581). MyGeneLog™. https://www.mygenelog.com/variants/rs7961581