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CYP2C19 *3 — clopidogrel activation

CYP2C19 · rs4986893

Where this position leads

Condition: CYP2C19 Metaboliser Status

Drugs: Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole

rs4986893 Condition: CYP2C19 Metaboliser Status CYP2C19 Metaboliser Status Condition Drug: Brivaracetam Brivaracetam Drug Drug: Clopidogrel Clopidogrel Drug Drug: Proton pump inhibitors Proton pump inhibitors Drug Drug: Serotonin reuptake antidepressants Serotonin reuptake antidepressants Drug Drug: Voriconazole Voriconazole Drug Topic: Heart and circulation Heart and circulation Topic rs4986893 rs4986893 CYP2C19

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What ClinVar records

Classification drug response for MEPHENYTOIN, POOR METABOLISM OF, PROGUANIL, POOR METABOLISM OF, CYP2C19: no function, Acute coronary syndrome, Clopidogrel response; practice guideline (4 of 4 stars, 6 submitters). ClinVar record 16899 NM_000769.1(CYP2C19):c.636G>A (p.Trp212Ter)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of CYP2C19*3 — no functioning enzyme from this position, with the same consequence for clopidogrel as two copies of *2.
A/G One copy of CYP2C19*3, a no-function allele. It does the same thing as *2 and is found more often in east Asian populations, which is why a CYP2C19 panel that tests only *2 misclassifies more people there.
G/G No copy of *3 at this position.
This is a pharmacogenomic result with a published dosing guideline behind it. Tell a prescriber or pharmacist rather than acting on it — and never stop or change a prescribed medicine on the strength of a genotype.
Source
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update
Lee CR, Luzum JA, Sangkuhl K, Gammal RS, Sabatine MS, Stein CM, Kisor DF, Limdi NA, Lee YM, Scott SA, Hulot JS, Roden DM
and 5 more — show all
Gaedigk A, Caudle KE, Klein TE, Johnson JA, Shuldiner AR
Clinical pharmacology and therapeutics · 2022 · PMID 35034351

What people read about alongside this

Heart and circulation10 Blood sugar and insulin2 Depression and stress2 Kidneys1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4986893

What is rs4986893?

rs4986893 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with cyp2c19 *3 — clopidogrel activation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4986893 linked to?

On MyGeneLog this position is linked to CYP2C19 Metaboliser Status. The research behind each link, and its sources, are set out on that condition page.

Does rs4986893 affect how medicines work?

CYP2C19 carries pharmacogenomic findings for Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs4986893?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (10 papers), blood sugar and insulin (2 papers), depression and stress (2 papers), kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4986893 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4986893 come from?

CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update, Clinical Pharmacology & Therapeutics (PMID 35034351). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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CYP2C19 *3 — clopidogrel activation (rs4986893). MyGeneLog™. https://www.mygenelog.com/variants/rs4986893

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