Caffeine metabolism
CYP1A2 · rs762551
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classification
Likely benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-03-09.
ClinVar record 511079 NM_000761.5(CYP1A2):c.-9-154C>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
From our blog
Questions about rs762551
What is rs762551?
rs762551 is a single position in the genome, in or near the CYP1A2 gene. Published research associates it with caffeine metabolism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs762551 linked to?
On MyGeneLog this position is linked to Caffeine Metabolism (CYP1A2). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs762551?
Subjects that appear in the title or abstract of the same papers as this rsID include caffeine and energy drinks (42 papers), blood sugar and insulin (8 papers), running and endurance (7 papers), sleep and insomnia (3 papers), heart and circulation (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs762551 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs762551 come from?
Cornelis et al. 2006, JAMA — coffee, CYP1A2 genotype, and risk of myocardial infarction. PMID 16522833. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Caffeine metabolism (rs762551). MyGeneLog™. https://www.mygenelog.com/variants/rs762551