Standard
Lipoprotein-associated phospholipase A2 activity and mass
CELSR2 · rs7528419
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lipoprotein-associated phospholipase A2 activity and mass compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lipoprotein-associated phospholipase A2 activity and mass.
G/G
Published research associates this genotype with typical/baseline likelihood of Lipoprotein-associated phospholipase A2 activity and mass — no copies of the reported risk allele.
Source
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies
Grallert H,
Dupuis J,
Bis JC,
Dehghan A,
Barbalic M,
Baumert J,
Lu C,
Smith NL,
Uitterlinden AG,
Roberts R,
Khuseyinova N,
Schnabel RB
and 33 more — show all
Rice KM,
Rivadeneira F,
Hoogeveen RC,
Fontes JD,
Meisinger C,
Keaney JF Jr,
Lemaitre R,
Aulchenko YS,
Vasan RS,
Ellis S,
Hazen SL,
van Duijn CM,
Nelson JJ,
März W,
Schunkert H,
McPherson RM,
Stirnadel-Farrant HA,
Psaty BM,
Gieger C,
Siscovick D,
Hofman A,
Illig T,
Cushman M,
Yamamoto JF,
Rotter JI,
Larson MG,
Stewart AF,
Boerwinkle E,
Witteman JC,
Tracy RP,
Koenig W,
Benjamin EJ,
Ballantyne CM
European heart journal · 2012 · PMID 22003152
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs7528419
What is rs7528419?
rs7528419 is a single position in the genome, in or near the CELSR2 gene. Published research associates it with lipoprotein-associated phospholipase a2 activity and mass. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs7528419?
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (3 papers), blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs7528419 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7528419 come from?
GWAS Catalog, Eur Heart J 2011, PMID:22003152. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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