VKORC1 · rs9923231
Where this position leads
Condition: Warfarin Sensitivity and Anticoagulant Dose Variability
Drug: Warfarin
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classification
drug response for Warfarin response, phenprocoumon response - Toxicity, phenprocoumon response - Dosage, warfarin response - Toxicity, Venous thromboembolism and 5 more; reviewed by expert panel (3 of 4 stars, 9 submitters), last evaluated 2021-11-19.
ClinVar record 2211 NM_024006.4(VKORC1):c.-1639G>A
Classification
drug response for Warfarin response; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2006-12-16.
ClinVar record 166563 NC_000016.10:g.31096368=
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs9923231 is a single position in the genome, in or near the VKORC1 gene. Published research associates it with warfarin sensitivity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Warfarin Sensitivity and Anticoagulant Dose Variability. The research behind each link, and its sources, are set out on that condition page.
VKORC1 carries pharmacogenomic findings for Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (12 papers), bones and fractures (3 papers), natural selection (2 papers), cholesterol and blood fats (1 papers), kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Rieder et al. 2005, New England Journal of Medicine — effect of VKORC1 haplotypes on transcription and warfarin dose. PMID 15930419. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Warfarin sensitivity (rs9923231). MyGeneLog™. https://www.mygenelog.com/variants/rs9923231