CYP17A1 · rs4919687
Where this position leads
Condition: Colorectal Cancer
What the study found
Who was studied 4,508 East Asian ancestry cases, 16,588 East Asian ancestry controls; replicated in 11,044 East Asian ancestry cases, 18,036 East Asian ancestry controls.
The effect Each copy of the G allele carried 1.14 times the odds of Colorectal cancer (95% confidence interval 1.10-1.19); p = 8 × 10−12.
How common The G allele had a frequency of about 80% in the people studied.
Where it sits Chromosome 10, band 10q24.32 — in an intron of CYP17A1.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2026-02-02.
ClinVar record 1292585 NM_000102.4(CYP17A1):c.298-99C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs4919687 is a single position in the genome, in or near the CYP17A1 gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Gastroenterology 2016, PMID:26965516. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Colorectal cancer (rs4919687). MyGeneLog™. https://www.mygenelog.com/variants/rs4919687