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Atrial fibrillation

SYNPO2L · rs10824026

Where this position leads

Condition: Atrial Fibrillation

rs10824026 Condition: Atrial Fibrillation Atrial Fibrillation Condition Topic: Heart and circulation Heart and circulation Topic rs10824026 rs10824026 SYNPO2L

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 6,707 European ancestry cases, 52,426 European ancestry controls; replicated in 5,381 European ancestry casses, 10,030 European ancestry controls.

The effect Each copy of the A allele carried 1.15 times the odds of Atrial fibrillation (95% confidence interval 1.10-1.20); p = 4 × 10−9.

How common The A allele had a frequency of about 84% in the people studied.

Where it sits Chromosome 10, band 10q22.2 — in an intron of SYNPO2L-AS1.

What each result means

A/A Two copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/G No copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10824026

What is rs10824026?

rs10824026 is a single position in the genome, in or near the SYNPO2L gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10824026 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10824026?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (5 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10824026 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10824026 come from?

GWAS Catalog, Nat Genet 2012, PMID:22544366. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (rs10824026). MyGeneLog™. https://www.mygenelog.com/variants/rs10824026

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