IL23R · rs11209026
Where this position leads
Condition: Crohn's Disease
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 1,277 European ancestry cases, 1,488 European ancestry controls; replicated in 1,365 European ancestry cases, 1,396 European ancestry controls.
The effect Each copy of the G allele carried 2.84 times the odds of Crohn's disease; p = 4 × 10−14.
Where it sits Chromosome 1, band 1p31.3 — a missense change in IL23R.
What ClinVar records
Classification
Benign for Inflammatory bowel disease 17, protection against, Psoriasis, protection against; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2026-02-03.
ClinVar record 3108 NM_144701.3(IL23R):c.1142G>A (p.Arg381Gln)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs11209026 is a single position in the genome, in or near the IL23R gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include gut and food intolerance (4 papers), blood sugar and insulin (2 papers), infection and immunity (2 papers), fertility (1 papers), alcohol and the flush (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Gut 2012, PMID:22936669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Crohn's disease (rs11209026). MyGeneLog™. https://www.mygenelog.com/variants/rs11209026