KCNJ11 · rs5215
Where this position leads
Condition: Type 2 Diabetes
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 1,924 European ancestry cases, 2,938 European ancestry controls; replicated in 3,757 European ancestry cases, 5,346 European ancestry controls.
The effect Each copy of the C allele carried 1.14 times the odds of Type 2 diabetes (95% confidence interval 1.10-1.19); p = 5 × 10−11.
Where it sits Chromosome 11, band 11p15.1 — a missense change in KCNJ11.
What ClinVar records
Classification
Benign/Likely benign for Diabetes mellitus, transient neonatal, 3, Maturity-onset diabetes of the young type 13, Hyperinsulinemic hypoglycemia, familial, 2, Permanent neonatal diabetes mellitus, Diabetes mellitus, permanent neonatal 2 and 1 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 14 submitters), last evaluated 2026-02-04.
ClinVar record 158670 NM_000525.4(KCNJ11):c.1009G>A (p.Val337Ile)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs5215 is a single position in the genome, in or near the KCNJ11 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (21 papers), heart and circulation (3 papers), caffeine and energy drinks (1 papers), exercise and muscle (1 papers), brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Science 2007, PMID:17463249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs5215). MyGeneLog™. https://www.mygenelog.com/variants/rs5215