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Fibrinogen

FGB · rs1800789

Where this position leads

Condition: Fibrinogen and Blood Clotting

rs1800789 Condition: Fibrinogen and Blood Clotting Fibrinogen and Blood Clotting Condition rs1800789 rs1800789 FGB

What the study found

Who was studied 22,096 European ancestry individuals; replicated in 17,686 European ancestry female individuals.

The effect Each copy of the A allele shifted the measure 0.09 g/L higher (95% confidence interval 0.07-0.11); p = 2 × 10−30.

How common The A allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 4, band 4q31.3 — between genes, 1.4 kb from FGB.

What each result means

A/A Two copies of the version the research linked to Fibrinogen. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Fibrinogen. That is a smaller link than two copies.
G/G No copy of the version the research linked to Fibrinogen. This is the starting point the study compared everyone against.
Source
Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts
Dehghan A, Yang Q, Peters A, Basu S, Bis JC, Rudnicka AR, Kavousi M, Chen MH, Baumert J, Lowe GD, McKnight B, Tang W
and 29 more — show all
de Maat M, Larson MG, Eyhermendy S, McArdle WL, Lumley T, Pankow JS, Hofman A, Massaro JM, Rivadeneira F, Kolz M, Taylor KD, van Duijn CM, Kathiresan S, Illig T, Aulchenko YS, Volcik KA, Johnson AD, Uitterlinden AG, Tofler GH, Gieger C, Psaty BM, Couper DJ, Boerwinkle E, Koenig W, O'Donnell CJ, Witteman JC, Strachan DP, Smith NL, Folsom AR
Wellcome Trust Case Control Consortium
Circulation. Cardiovascular genetics · 2009 · PMID 20031576

What people read about alongside this

Heart and circulation1 Brain and memory1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1800789

What is rs1800789?

rs1800789 is a single position in the genome, in or near the FGB gene. Published research associates it with fibrinogen. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1800789 linked to?

On MyGeneLog this position is linked to Fibrinogen and Blood Clotting. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1800789?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (1 papers), brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1800789 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1800789 come from?

GWAS Catalog, Circ Cardiovasc Genet 2009, PMID:20031576. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Fibrinogen (rs1800789). MyGeneLog™. https://www.mygenelog.com/variants/rs1800789

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