4 5232623222228Reads by AI crawlersClaude3ChatGPT2Google · Gemini6Perplexity2Meta AI3Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others28Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 5,406 European ancestry cases, 15,112 European ancestry controls; replicated in 7,330 European ancestry cases, 61,156 European ancestry controls.
The effect
Each copy of the T allele carried 1.10 times the odds of Longevity (90 years and older) (95% confidence interval 1.06-1.74); p = 2 × 10−8.
How common The T allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 5, band 5q33.3 — in an intron of LINC02227.
What each result means
C/CNo copy of the version the research linked to Longevity (90 years and older). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Longevity (90 years and older). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Longevity (90 years and older). That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs2149954
What is rs2149954?
rs2149954 is a single position in the genome, in or near the EBF1 gene. Published research associates it with longevity (90 years and older). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2149954 linked to?
On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs2149954?
Subjects that appear in the title or abstract of the same papers as this rsID include longevity and ageing (3 papers), heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs2149954 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2149954 come from?
GWAS Catalog, Hum Mol Genet 2014, PMID:24688116. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 5232623222228Reads by AI crawlersClaude3ChatGPT2Google · Gemini6Perplexity2Meta AI3Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others28Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Longevity (90 years and older) (rs2149954). MyGeneLog™. https://www.mygenelog.com/variants/rs2149954