Standard

LDL cholesterol

APOE · rs4420638

Where this position leads

Drug: Lecanemab and other anti-amyloid antibodies

rs4420638 Drug: Lecanemab and other anti-amyloid antibodies Lecanemab and other anti-amyloid antibodies Drug rs4420638 APOE

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of LDL cholesterol — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2008, PMID:18193043)
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with LDL cholesterol. (GWAS Catalog, Nat Genet 2008, PMID:18193043)
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of LDL cholesterol compared to the general population. (GWAS Catalog, Nat Genet 2008, PMID:18193043)

Source: GWAS Catalog, Nat Genet 2008, PMID:18193043

What people read about alongside this

Longevity and ageing4 Alcohol and the flush1 Depression and stress1 Learning and focus1 Brain and memory1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4420638

What is rs4420638?

rs4420638 is a single position in the genome, in or near the APOE gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs4420638 affect how medicines work?

APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs4420638?

Subjects that appear in the title or abstract of the same papers as this rsID include longevity and ageing (4 papers), alcohol and the flush (1 papers), depression and stress (1 papers), learning and focus (1 papers), brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4420638 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4420638 come from?

GWAS Catalog, Nat Genet 2008, PMID:18193043. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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