APOE · rs4420638
Where this position leads
Condition: Cholesterol (LDL, HDL and Total)
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 8,589 European ancestry individuals; replicated in 12,981 European ancestry individuals.
The effect Each copy of the G allele shifted the measure 6.61 mg/dl higher; p = 3 × 10−43.
How common The G allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — inside APOC1.
What ClinVar records
Classification
not provided; no classification provided (0 of 4 stars, 1 submitter).
ClinVar record 162177 NC_000019.10:g.44919689A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs4420638 is a single position in the genome, in or near the APOE gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (14 papers), blood sugar and insulin (7 papers), heart and circulation (6 papers), longevity and ageing (4 papers), brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2008, PMID:18193043. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
LDL cholesterol (rs4420638). MyGeneLog™. https://www.mygenelog.com/variants/rs4420638