PRDM16 · rs2483280
Where this position leads
Condition: Cardiac Conduction Intervals (PR Interval and QRS Duration)
What the study found
Who was studied 6,085 Korean ancestry individuals; replicated in 7,295 Japanese ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.75 lower; p = 2 × 10−11.
How common The A allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 1, band 1p36.32 — in an intron of PRDM16.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs2483280 is a single position in the genome, in or near the PRDM16 gene. Published research associates it with qrs duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cardiac Conduction Intervals (PR Interval and QRS Duration). The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hum Mol Genet 2014, PMID:25035420. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
QRS duration (rs2483280). MyGeneLog™. https://www.mygenelog.com/variants/rs2483280