Standard

Alcohol metabolism speed

ADH1B · rs1229984

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Where this position leads

Condition: ALDH2 Deficiency (Alcohol Flush Reaction)

rs1229984 Condition: ALDH2 Deficiency (Alcohol Flush Reaction) ALDH2 Deficiency (Alcohol Flush Reaction) Condition rs1229984 ADH1B

What each result means

A/A Published research associates this genotype with substantially faster conversion of alcohol to acetaldehyde. Common in East Asian populations and often co-occurs with the ALDH2 flush variant (see rs671).
G/A Published research associates this genotype with faster conversion of alcohol to acetaldehyde, which can produce more pronounced effects from a given amount of alcohol and is associated with lower rates of heavy drinking in population studies.
G/G Typical ADH1B enzyme activity in published research — alcohol is converted to acetaldehyde at the usual rate.

Source: Edenberg 2007, Alcohol Research & Health — the genetics of alcohol metabolism (ADH and ALDH gene families).

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