ADH1B · rs1229984
Where this position leads
Condition: ALDH2 Deficiency (Alcohol Flush Reaction)
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classification
protective for Alcohol dependence, Aerodigestive tract cancer, squamous cell, alcohol-related, protection against; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2018-06-04.
ClinVar record 18182 NM_000668.5(ADH1B):c.143A= (p.His48=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs1229984 is a single position in the genome, in or near the ADH1B gene. Published research associates it with alcohol metabolism speed. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to ALDH2 Deficiency (Alcohol Flush Reaction). The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include alcohol and the flush (100 papers), liver (14 papers), natural selection (8 papers), blood sugar and insulin (7 papers), heart and circulation (6 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Edenberg 2007, Alcohol Research & Health — the genetics of alcohol metabolism (ADH and ALDH gene families). PMID 17718394. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alcohol metabolism speed (rs1229984). MyGeneLog™. https://www.mygenelog.com/variants/rs1229984