Fasting plasma glucose
G6PC2 · rs560887
Where this position leads
Condition: Osteoarthritis
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 35,812 European ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.06 mmol/l higher (95% confidence interval 0.05-0.07); p = 1 × 10−57.
How common The C allele had a frequency of about 70% in the people studied.
Where it sits Chromosome 2, band 2q31.1 — in an intron of G6PC2.
What each result means
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
In the news
2026-06-01 · Brito Nunes C, et al., Nature Communications 2026, PMID:42225636
Gestational diabetes affects about 14% of pregnancies and raises the mother's later risk of type 2 diabetes. The GenDiP Consortium's meta-analysis covers up to 38,305 women with gestational diabetes and 776,145 controls and finds 37 associated loci, 7 of them new, plus five new loci for blood sugar traits in pregnancy — all acting through the mother's genome rather than the baby's. Every locus overlaps type 2 diabetes or glycaemic traits outside pregnancy, which is the 'limited evidence' of the title; but 12 variants have stronger effects in gestational diabetes than in type 2 diabetes, four loci (G6PC2, CAST-PCSK1, HKDC1, FOXA2) have no genome-wide-significant type 2 diabetes association, GCK shows distinct causal variants, and MTNR1B's effect is amplified in pregnancy. Seven of the study's positions are on this site under other traits, including rs560887 (G6PC2), rs11558471 (SLC30A8), rs849134 (JAZF1) and rs4665972 (GCKR). It sits beside this site's gestational diabetes page, which is built on a separate 2026 study. PMID:42225636.
2026-05-22 · Sinnott-Armstrong N, et al., Nature Communications 2026, PMID:42173832
Genetic variants affect diurnal glucose levels throughout the day
Circadian rhythms regulate glucose metabolism as well as sleep, but which genetic variants govern the timing of glucose had not been examined. Using the time of day each blood sample was taken, this study of about 420,000 UK Biobank participants — replicated in the Estonian Biobank, FinnGen, the VA Million Veteran Program and the MGB Biobank — shows that glucose levels are under diurnal genetic control. The two robust time-dependent signals are at MTNR1B, the melatonin receptor (rs10830963), and at CRY2, a core circadian clock gene (rs12419690). Sleep modulated glucose levels, the variants acted independently of sleep, they independently changed the risk of type 2 diabetes, and sleep medications including melatonin were associated with type 2 diabetes. Those two headline positions are not on this site yet; 21 other positions from the study are, among them rs560887 (G6PC2), rs34872471 (TCF7L2), rs3802177 (SLC30A8) and rs11708067 (ADCY5). PMID:42173832.
From our blog
Questions about rs560887
What is rs560887?
rs560887 is a single position in the genome, in or near the G6PC2 gene. Published research associates it with fasting plasma glucose. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs560887 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs560887?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (27 papers), longevity and ageing (2 papers), natural selection (1 papers), exercise and muscle (1 papers), learning and focus (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs560887 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs560887 come from?
GWAS Catalog, Nat Genet 2008, PMID:19060907. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Fasting plasma glucose (rs560887). MyGeneLog™. https://www.mygenelog.com/variants/rs560887