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Anticoagulant levels

PROCR · rs867186

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 397 European ancestry individuals from 21 families.

The effect Each copy of the G allele shifted the measure 0.845 SD higher; p = 4 × 10⁻⁹.

How common The G allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 20, band 20q11.22 — a missense change in MMP24-AS1-EDEM2.

What each result means

A/A No copy of the version the research linked to Anticoagulant levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Anticoagulant levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Anticoagulant levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

A genome-wide association study of the Protein C anticoagulant pathway

Athanasiadis G, Buil A, Souto JC, Borrell M, López S, Martinez-Perez A, Lathrop M, Fontcuberta J, Almasy L, Soria JM

PloS one · 2011 · PMID 22216198 · open access

What people read about alongside this

Heart and circulation6 Blood sugar and insulin1 Natural selection1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs867186

What is rs867186?

rs867186 is a single position in the genome, in or near the PROCR gene. Published research associates it with anticoagulant levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs867186 linked to?

On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs867186?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (6 papers), blood sugar and insulin (1 papers), natural selection (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs867186 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs867186 come from?

GWAS Catalog, PLoS One 2011, PMID:22216198. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Anticoagulant levels (rs867186). MyGeneLog™. https://www.mygenelog.com/variants/rs867186

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