DARC / ACKR1 · rs2814778
Where this position leads
Condition: Duffy-Null Phenotype and Benign Ethnic Neutropenia
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classification
association; protective for Resistance to Plasmodium vivax infection, DUFFY BLOOD GROUP SYSTEM, FY(a-b-) PHENOTYPE, White blood cell count quantitative trait locus 1; no assertion criteria provided (0 of 4 stars, 2 submitters), last evaluated 2017-12-11.
ClinVar record 18395 NM_002036.3(ACKR1):c.-67T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs2814778 is a single position in the genome, in or near the DARC / ACKR1 gene. Published research associates it with duffy blood group (malaria resistance). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Duffy-Null Phenotype and Benign Ethnic Neutropenia. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include natural selection (3 papers), heart and circulation (1 papers), liver (1 papers), kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Miller et al. 1976, New England Journal of Medicine — the Duffy blood group phenotype and resistance to Plasmodium vivax malaria. PMID 778616. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Duffy blood group (malaria resistance) (rs2814778). MyGeneLog™. https://www.mygenelog.com/variants/rs2814778