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Bilirubin levels

UGT1A1 · rs887829

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 4,300 Sardinian individuals; replicated in 1,860 Sardinian individuals, 832 Old Order Amish individuals.

The effect Each copy of the T allele shifted the measure 0.57 s.d. lower (95% confidence interval 0.50-0.63); p = 1 × 10⁻⁶⁹.

How common The T allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 2, band 2q37.1 — in an intron of UGT1A5.

What each result means

C/C No copy of the version the research linked to Bilirubin levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Bilirubin levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Bilirubin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia

Sanna S, Busonero F, Maschio A, McArdle PF, Usala G, Dei M, Lai S, Mulas A, Piras MG, Perseu L, Masala M, Marongiu M

and 8 more — show all

Crisponi L, Naitza S, Galanello R, Abecasis GR, Shuldiner AR, Schlessinger D, Cao A, Uda M

Human molecular genetics · 2009 · PMID 19419973

What people read about alongside this

Blood sugar and insulin3 Heart and circulation2 Liver2 Vitamins and nutrient levels1 Sleep and insomnia1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs887829

What is rs887829?

rs887829 is a single position in the genome, in or near the UGT1A1 gene. Published research associates it with bilirubin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs887829 affect how medicines work?

UGT1A1 carries pharmacogenomic findings for Atazanavir, Irinotecan. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs887829?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (3 papers), heart and circulation (2 papers), liver (2 papers), vitamins and nutrient levels (1 papers), sleep and insomnia (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs887829 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs887829 come from?

GWAS Catalog, Hum Mol Genet 2009, PMID:19419973. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Bilirubin levels (rs887829). MyGeneLog™. https://www.mygenelog.com/variants/rs887829

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