5 681333423445Reads by AI crawlersClaude1ChatGPT3Google · Gemini3Perplexity3Meta AI4Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)4ByteDance (Doubao)4Others45Total68Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
ClassificationPathogenic/Pathogenic, low penetrance; risk factor for Hemochromatosis type 1, Hereditary cancer-predisposing syndrome, Hereditary hemochromatosis, Porphyrinuria, Cutaneous photosensitivity and 6 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 56 submitters), last evaluated 2026-08-31.
ClinVar record 9NM_000410.4(HFE):c.845G>A (p.Cys282Tyr)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the C282Y variant — the genotype most strongly associated with hereditary hemochromatosis, a condition where the body absorbs too much iron from food. Not everyone with this genotype develops iron overload, but published research associates it with substantially elevated risk compared to the general population.
G/AOne copy of the C282Y variant. Published research associates this genotype with carrier status — usually not enough to cause iron overload on its own, but relevant for family planning and if combined with other HFE variants.
G/GNo copies of the C282Y variant. Published research does not associate this genotype with elevated hereditary hemochromatosis risk from this variant.
This is a medically actionable finding. Talk to a doctor about a ferritin/iron panel blood test — hereditary hemochromatosis is manageable when caught early, typically with routine blood donation or therapeutic phlebotomy.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs1800562
What is rs1800562?
rs1800562 is a single position in the genome, in or near the HFE gene. Published research associates it with iron overload risk (hereditary hemochromatosis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1800562 linked to?
On MyGeneLog this position is linked to Hereditary Hemochromatosis (HFE). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs1800562?
Subjects that appear in the title or abstract of the same papers as this rsID include liver (6 papers), brain and memory (4 papers), blood sugar and insulin (4 papers), heart and circulation (3 papers), menopause (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs1800562 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1800562 come from?
Feder et al. 1996, Nature Genetics — a novel MHC class I-like gene (HFE) mutated in patients with hereditary haemochromatosis. PMID 8696333. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
5 681333423445Reads by AI crawlersClaude1ChatGPT3Google · Gemini3Perplexity3Meta AI4Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)4ByteDance (Doubao)4Others45Total68Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Iron overload risk (hereditary hemochromatosis) (rs1800562). MyGeneLog™. https://www.mygenelog.com/variants/rs1800562