5 5634347212228Reads by AI crawlersClaude3ChatGPT4Google · Gemini3Perplexity4Meta AI7Microsoft · Copilot2Amazon1Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others28Total56Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 39,717 East Asian ancestry individuals; replicated in 17,461 East Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0064 mg/dl higher (95% confidence interval 0.0042-0.0086); p = 2 × 10−9.
How common The A allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 12, band 12q24.13 — in an intron of HECTD4.
What each result means
A/ATwo copies of the version the research linked to Renal function-related traits (BUN). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Renal function-related traits (BUN). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Renal function-related traits (BUN). This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs2074356
What is rs2074356?
rs2074356 is a single position in the genome, in or near the C12orf51 gene. Published research associates it with renal function-related traits (bun). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2074356 linked to?
On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs2074356?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (7 papers), alcohol and the flush (6 papers), caffeine and energy drinks (5 papers), heart and circulation (1 papers), depression and stress (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs2074356 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2074356 come from?
GWAS Catalog, Nat Genet 2012, PMID:22797727. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
5 5634347212228Reads by AI crawlersClaude3ChatGPT4Google · Gemini3Perplexity4Meta AI7Microsoft · Copilot2Amazon1Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others28Total56Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.