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HIV-1 resistance (CCR5-delta32)

CCR5 · rs333

Where this position leads

Condition: CCR5-Delta32 and HIV-1 Resistance

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What ClinVar records

Classification Benign for Multiple sclerosis modifier of disease progression, Susceptibility to HIV infection, Resistance to hepatitis C virus, West Nile virus, susceptibility to, CCR5-related disorder; criteria provided, single submitter (1 of 4 stars, 3 submitters), last evaluated 2019-11-22. ClinVar record 8184 NM_001394783.1(CCR5):c.554_585del (p.Ser185fs)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

Del/Del Two copies of the CCR5-delta32 deletion — this well-studied variant removes the CCR5 co-receptor most HIV-1 strains use to enter immune cells. Published research associates this genotype with strong natural resistance to infection by most HIV-1 strains. This is a rare genotype, most common in Northern European populations.

Ins/Del One copy of the CCR5-delta32 deletion. Published research associates this genotype with somewhat slower HIV-1 disease progression if infected, but not resistance to infection itself.

Ins/Ins No copies of the CCR5-delta32 deletion. Typical CCR5 receptor expression.

This variant does not protect against all HIV-1 strains (some use a different co-receptor) or against other sexually transmitted infections. It is not a substitute for standard prevention.

Source

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C

and 10 more — show all

Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth RJ, Collman RG, Doms RW, Vassart G, Parmentier M

Nature · 1996 · PMID 8751444

What people read about alongside this

Blood sugar and insulin3 Heart and circulation3 Infection and immunity3 Vitamins and nutrient levels1 Gut and food intolerance1 Fertility1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

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Questions about rs333

What is rs333?

rs333 is a single position in the genome, in or near the CCR5 gene. Published research associates it with hiv-1 resistance (ccr5-delta32). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs333 linked to?

On MyGeneLog this position is linked to CCR5-Delta32 and HIV-1 Resistance. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs333?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (3 papers), heart and circulation (3 papers), infection and immunity (3 papers), vitamins and nutrient levels (1 papers), gut and food intolerance (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs333 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs333 come from?

Samson et al. 1996, Nature — resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR5 chemokine receptor gene. PMID 8751444. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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HIV-1 resistance (CCR5-delta32) (rs333). MyGeneLog™. https://www.mygenelog.com/variants/rs333

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