F5 · rs6025
Where this position leads
Conditions: Factor V Leiden Thrombophilia, Venous Thromboembolism
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classification
drug response for Ischemic stroke, Budd-Chiari syndrome, susceptibility to, Pregnancy loss, recurrent, susceptibility to, 1, Factor V deficiency, Thrombophilia due to activated protein C resistance and 5 more; reviewed by expert panel (3 of 4 stars, 29 submitters), last evaluated 2021-03-24.
ClinVar record 642 NM_000130.4(F5):c.1601G>A (p.Arg534Gln)
Classification
Conflicting classifications of pathogenicity for Congenital factor V deficiency, F5-related disorders; criteria provided, conflicting classifications (1 of 4 stars, 6 submitters), last evaluated 2026-02-04.
ClinVar record 226007 NM_000130.5(F5):c.1601= (p.Arg534=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
2023-10-19 · Uppsala University (Valeria Lo Faro, Therese Johansson, Åsa Johansson), covering research published in the American Journal of Obstetrics & Gynecology (244,420 women, UK Biobank)
Genetics Influence the Risk of Blood Clots in Oral Contraceptive Users
A UK Biobank study of 244,420 women found that those with a high genetic risk score had six times the blood-clot risk during the first two years of oral contraceptive use compared to women with a low genetic risk score -- a broader polygenic score, built on top of the established single-variant risk this site already covers: Factor V Leiden (rs6025) and the prothrombin variant (rs1799963), both known to raise clotting risk sharply when combined with hormonal contraceptives. The elevated risk was concentrated in the first two years of use, not sustained use.
rs6025 is a single position in the genome, in or near the F5 gene. Published research associates it with blood clotting risk (factor v leiden). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Factor V Leiden Thrombophilia, Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.
F5 carries pharmacogenomic findings for Combined hormonal contraceptives. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (13 papers), alcohol and the flush (2 papers), running and endurance (2 papers), kidneys (2 papers), exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Bertina et al. 1994, Nature — mutation in blood coagulation factor V associated with resistance to activated protein C. PMID 8164741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Blood clotting risk (Factor V Leiden) (rs6025). MyGeneLog™. https://www.mygenelog.com/variants/rs6025