4 4622126222225Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity2Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others25Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 17,967 European ancestry and Indian Asian ancestry individuals; replicated in 13,615 European ancestry and Indian Asian ancestry Individuals.
The effect
Each copy of the T allele shifted the measure 11.5 % lower (95% confidence interval 8.5-14.4); p = 2 × 10−14.
Where it sits Chromosome 1, band 1q21.3 — in an intron of IL6R.
What each result means
C/CNo copy of the version the research linked to C-reactive protein. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to C-reactive protein. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to C-reactive protein. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs4537545
What is rs4537545?
rs4537545 is a single position in the genome, in or near the IL6R gene. Published research associates it with c-reactive protein. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4537545 linked to?
On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs4537545?
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs4537545 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4537545 come from?
GWAS Catalog, JAMA 2009, PMID:19567438. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 4622126222225Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity2Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others25Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
C-reactive protein (rs4537545). MyGeneLog™. https://www.mygenelog.com/variants/rs4537545