ACAD10 · rs11066015
Where this position leads
Condition: Oesophageal Cancer
What the study found
Who was studied 2,031 Han Chinese ancestry cases, 2,044 Han Chinese ancestry controls; replicated in 3,986 Han Chinese ancestry cases, 4,157 Han Chinese ancestry controls.
The effect Each copy of the A allele carried 1.38 times the odds of Esophageal cancer (95% confidence interval 1.29-1.48); p = 7 × 10−21.
How common The A allele had a frequency of about 19% in the people studied.
Where it sits Chromosome 12, band 12q24.12 — in an intron of ACAD10.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
2026-01-28 · Namba S, et al., Nature 2026, PMID:41606330
A cross-population compendium of gene-environment interactions
An atlas of gene-environment interactions — where a variant's effect size differs by age, sex or lifestyle — built from 440,210 people of European and Japanese ancestry and replicated in 539,794 more from diverse populations. Decomposing the contributions of age, sex and lifestyle exposed the aetiology of these interactions, including reverse causality from disease-driven changes in diet, and showed that they affect polygenic prediction accuracy and how well scores transfer across populations. Omics-level analyses found sex-discordant genetic effects in lipid metabolism, which the authors connect to failures of genetically supported drug trials. The variant that dominates this catalogue's overlap with the study is rs671 in ALDH2 — the alcohol flush variant — whose effects on liver enzymes (AST, ALT), HDL cholesterol and red-cell indices differ by sex, ever-drinking and smoking; also on this site from the study: rs145954970 (SLC22A11, uric acid, gout), rs11066015 (ACAD10, red-cell count by drinking), rs730154 (CYP19A1, height by sex) and rs35747824 (PDILT, creatinine by age). PMID:41606330.
rs11066015 is a single position in the genome, in or near the ACAD10 gene. Published research associates it with esophageal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Oesophageal Cancer. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), caffeine and energy drinks (1 papers), heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2011, PMID:21642993. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Esophageal cancer (rs11066015). MyGeneLog™. https://www.mygenelog.com/variants/rs11066015