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Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 99,900 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.73 mg/dL lower (95% confidence interval 0.57-0.89); p = 2 × 10−22.
How common The T allele had a frequency of about 36% in the people studied.
Where it sits Chromosome 11, band 11q12.2 — in the 3′ untranslated region of FADS1.
What each result means
C/CNo copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs174546
What is rs174546?
rs174546 is a single position in the genome, in or near the FADS1 gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs174546 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs174546?
Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (9 papers), blood sugar and insulin (3 papers), heart and circulation (2 papers), allergies (1 papers), depression and stress (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs174546 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs174546 come from?
GWAS Catalog, Nature 2010, PMID:20686565. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
6 514226222229Reads by AI crawlersClaude4ChatGPT2Google · Gemini0Perplexity2Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others29Total51Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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