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Triglycerides

MLXIPL · rs3812316

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 1,005 European ancestry male individuals, 1,006 Indian Asian ancestry male individuals; replicated in 6,827 European ancestry individuals, 2,528 Mexican ancestry individuals, 1,181 Indian Asian ancestry female individuals.

The effect Each copy of the C allele shifted the measure 10.5 % higher (95% confidence interval 5.3-17.7); p = 1 × 10⁻¹⁰.

How common The C allele had a frequency of about 95% in the people studied.

Where it sits Chromosome 7, band 7q11.23 — a missense change in MLXIPL.

What each result means

C/C Two copies of the version the research linked to Triglycerides. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Triglycerides. That is a smaller link than two copies.

G/G No copy of the version the research linked to Triglycerides. This is the starting point the study compared everyone against.

Source

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, Gómez Pérez FJ, Frazer KA, Elliott P, Scott J, Milos PM, Cox DR

and 1 more — show all

Thompson JF

Nature genetics · 2008 · PMID 18193046

What people read about alongside this

Cholesterol and blood fats4 Heart and circulation3 Blood sugar and insulin2 Menopause1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs3812316

What is rs3812316?

rs3812316 is a single position in the genome, in or near the MLXIPL gene. Published research associates it with triglycerides. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3812316 linked to?

On MyGeneLog this position is linked to High Triglycerides. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs3812316?

Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (4 papers), heart and circulation (3 papers), blood sugar and insulin (2 papers), menopause (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs3812316 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3812316 come from?

GWAS Catalog, Nat Genet 2008, PMID:18193046. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Triglycerides (rs3812316). MyGeneLog™. https://www.mygenelog.com/variants/rs3812316

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