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Plasma plasminogen activator levels

POLB · rs3136739

Where this position leads

Condition: Fibrinogen and Blood Clotting

rs3136739 Condition: Fibrinogen and Blood Clotting Fibrinogen and Blood Clotting Condition rs3136739 rs3136739 POLB

What the study found

Who was studied 26,217 European ancestry individuals, 712 Orcadian individuals; replicated in 4,487 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.063 higher (95% confidence interval 0.043-0.083); p = 1 × 10−9.

How common The A allele had a frequency of about 95% in the people studied.

Where it sits Chromosome 8, band 8p11.21 — in an intron of POLB.

What each result means

A/A Two copies of the version the research linked to Plasma plasminogen activator levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Plasma plasminogen activator levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Plasma plasminogen activator levels. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs3136739

What is rs3136739?

rs3136739 is a single position in the genome, in or near the POLB gene. Published research associates it with plasma plasminogen activator levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3136739 linked to?

On MyGeneLog this position is linked to Fibrinogen and Blood Clotting. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs3136739?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs3136739 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3136739 come from?

GWAS Catalog, Arterioscler Thromb Vasc Biol 2014, PMID:24578379. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Plasma plasminogen activator levels (rs3136739). MyGeneLog™. https://www.mygenelog.com/variants/rs3136739

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