Standard
Plasma plasminogen activator levels
POLB · rs3136739
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Plasma plasminogen activator levels compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Plasma plasminogen activator levels.
G/G
Published research associates this genotype with typical/baseline likelihood of Plasma plasminogen activator levels — no copies of the reported risk allele.
Source
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2
Huang J,
Huffman JE,
Yamakuchi M,
Trompet S,
Asselbergs FW,
Sabater-Lleal M,
Trégouët DA,
Chen WM,
Smith NL,
Kleber ME,
Shin SY,
Becker DM
and 81 more — show all
Tang W,
Dehghan A,
Johnson AD,
Truong V,
Folkersen L,
Yang Q,
Oudot-Mellkah T,
Buckley BM,
Moore JH,
Williams FM,
Campbell H,
Silbernagel G,
Vitart V,
Rudan I,
Tofler GH,
Navis GJ,
Destefano A,
Wright AF,
Chen MH,
de Craen AJ,
Worrall BB,
Rudnicka AR,
Rumley A,
Bookman EB,
Psaty BM,
Chen F,
Keene KL,
Franco OH,
Böhm BO,
Uitterlinden AG,
Carter AM,
Jukema JW,
Sattar N,
Bis JC,
Bis JC,
Ikram MA,
Sale MM,
McKnight B,
Fornage M,
Ford I,
Taylor K,
Slagboom PE,
McArdle WL,
Hsu FC,
Franco-Cereceda A,
Goodall AH,
Yanek LR,
Furie KL,
Cushman M,
Hofman A,
Witteman JC,
Folsom AR,
Basu S,
Matijevic N,
van Gilst WH,
Wilson JF,
Westendorp RG,
Kathiresan S,
Reilly MP,
Tracy RP,
Polasek O,
Winkelmann BR,
Grant PJ,
Hillege HL,
Cambien F,
Stott DJ,
Lowe GD,
Spector TD,
Meigs JB,
Marz W,
Eriksson P,
Becker LC,
Morange PE,
Soranzo N,
Williams SM,
Hayward C,
van der Harst P,
Hamsten A,
Lowenstein CJ,
Strachan DP,
O'Donnell CJ
Arteriosclerosis, thrombosis, and vascular biology · 2014 · PMID 24578379
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs3136739
What is rs3136739?
rs3136739 is a single position in the genome, in or near the POLB gene. Published research associates it with plasma plasminogen activator levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs3136739?
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs3136739 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3136739 come from?
GWAS Catalog, Arterioscler Thromb Vasc Biol 2014, PMID:24578379. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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