BCHE · rs1803274
Where this position leads
Condition: Cardiovascular Disease Risk Factors
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 11,683 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.365 units/l lower (95% confidence interval 0.33-0.40); p = 6 × 10−92.
How common The T allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 3, band 3q26.1 — a missense change in LINC01322.
What ClinVar records
Classification
Conflicting classifications of pathogenicity for Butyrylcholinesterase activity, Deficiency of butyrylcholinesterase; criteria provided, conflicting classifications (1 of 4 stars, 9 submitters), last evaluated 2026-06-22.
ClinVar record 13220 NM_000055.2(BCHE):c.1699G>A (p.Ala567Thr)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs1803274 is a single position in the genome, in or near the BCHE gene. Published research associates it with cardiovascular disease risk factors. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cardiovascular Disease Risk Factors. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (4 papers), caffeine and energy drinks (1 papers), depression and stress (1 papers), heart and circulation (1 papers), fertility (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, BMC Med Genet 2011, PMID:21943158. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cardiovascular disease risk factors (rs1803274). MyGeneLog™. https://www.mygenelog.com/variants/rs1803274