MCM6 / LCT · rs4988235
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classification
association for LACTASE PERSISTENCE; no assertion criteria provided (0 of 4 stars, 2 submitters), last evaluated 2021-01-26.
ClinVar record 7685 NM_002299.2(LCT):c.-13907C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
2026-02-13 · Uppsala University & University of Gothenburg (two companion GWAS studies, Nature Genetics; >16,000 Swedish adults + 12,000+ Norwegian replication cohort)
11 Genetic Variants Linked to Gut Microbiome Composition via GWAS
Two companion GWAS papers (Uppsala University's Tove Fall and University of Gothenburg's Claes Ohlsson, in Nature Genetics) analyzed gut bacteria composition in over 16,000 Swedish adults and replicated the findings in 12,000+ Norwegians, confirming 11 genetic variants that shape the gut microbiome -- 9 newly discovered, plus 2 already known: LCT (lactase, rs4988235, profiled on this site) and ABO (blood type). The LCT finding is a direct mechanistic explanation for why lactase non-persistence reshapes gut bacteria, not just lactose digestion. Northern European cohorts only -- the researchers themselves caution results may not generalize globally.
rs4988235 is a single position in the genome, in or near the MCM6 / LCT gene. Published research associates it with lactose tolerance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Lactose Intolerance (Lactase Persistence). The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include gut and food intolerance (22 papers), blood sugar and insulin (13 papers), natural selection (7 papers), bones and fractures (6 papers), exercise and muscle (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Enattah et al. 2002, Nature Genetics — identification of a variant associated with adult-type hypolactasia. PMID 11788828. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lactose tolerance (rs4988235). MyGeneLog™. https://www.mygenelog.com/variants/rs4988235