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B-type natriuretic peptide levels

NPPB · rs198389

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,790 Black individuals.

The effect Each copy of the G allele shifted the measure 0.18 higher (95% confidence interval 0.12-0.24); p = 1 × 10⁻⁹.

How common The G allele had a frequency of about 40% in the people studied.

Where it sits Chromosome 1, band 1p36.22 — between genes, 0.2 kb from NPPB.

What each result means

A/A No copy of the version the research linked to B-type natriuretic peptide levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to B-type natriuretic peptide levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to B-type natriuretic peptide levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association analysis of plasma B-type natriuretic peptide in blacks: the Jackson Heart Study

Musani SK, Fox ER, Kraja A, Bidulescu A, Lieb W, Lin H, Beecham A, Chen MH, Felix JF, Fox CS, Kao WH, Kardia SL

and 11 more — show all

Liu CT, Nalls MA, Rundek T, Sacco RL, Smith J, Sun YV, Wilson G, Zhang Z, Mosley TH, Taylor HA, Vasan RS

Circulation. Cardiovascular genetics · 2015 · PMID 25561047

What people read about alongside this

Heart and circulation14 Blood sugar and insulin5 Longevity and ageing1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs198389

What is rs198389?

rs198389 is a single position in the genome, in or near the NPPB gene. Published research associates it with b-type natriuretic peptide levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs198389?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (14 papers), blood sugar and insulin (5 papers), longevity and ageing (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs198389 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs198389 come from?

GWAS Catalog, Circ Cardiovasc Genet 2015, PMID:25561047. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

B-type natriuretic peptide levels (rs198389). MyGeneLog™. https://www.mygenelog.com/variants/rs198389

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