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Atrial fibrillation

GNB4 · rs7612445

Where this position leads

Condition: Atrial Fibrillation

rs7612445 Condition: Atrial Fibrillation Atrial Fibrillation Condition rs7612445 rs7612445 GNB4

What the study found

Who was studied 60,620 European ancestry cases, 970,216 European ancestry controls.

The effect Each copy of the T allele carried 1.05 times the odds of Atrial fibrillation (95% confidence interval 1.03-1.07); p = 5 × 10−9.

How common The T allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 3, band 3q26.33 — inside GNB4.

What each result means

G/G No copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs7612445

What is rs7612445?

rs7612445 is a single position in the genome, in or near the GNB4 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7612445 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs7612445?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs7612445 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7612445 come from?

GWAS Catalog, Nat Genet 2018, PMID:30061737. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (rs7612445). MyGeneLog™. https://www.mygenelog.com/variants/rs7612445

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