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Menarche (age at onset)

KCNK9 · rs1469039

Where this position leads

What the study found

Who was studied Up to 182,413 European ancestry females.

The effect Each copy of the A allele shifted the measure 0.05 higher (95% confidence interval 0.036-0.064); p = 4 × 10⁻¹².

How common The A allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 8, band 8q24.3 — in an intron of KCNK9.

What each result means

A/A Two copies of the version the research linked to Menarche (age at onset). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Menarche (age at onset). That is a smaller link than two copies.

G/G No copy of the version the research linked to Menarche (age at onset). This is the starting point the study compared everyone against.

Source

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, Albrecht E, Ang WQ

and 186 more — show all

Corre T, Cousminer DL, Feenstra B, Franceschini N, Ganna A, Johnson AD, Kjellqvist S, Lunetta KL, McMahon G, Nolte IM, Paternoster L, Porcu E, Smith AV, Stolk L, Teumer A, Tšernikova N, Tikkanen E, Ulivi S, Wagner EK, Amin N, Bierut LJ, Byrne EM, Hottenga JJ, Koller DL, Mangino M, Pers TH, Yerges-Armstrong LM, Zhao JH, Andrulis IL, Anton-Culver H, Atsma F, Bandinelli S, Beckmann MW, Benitez J, Blomqvist C, Bojesen SE, Bolla MK, Bonanni B, Brauch H, Brenner H, Buring JE, Chang-Claude J, Chanock S, Chen J, Chenevix-Trench G, Collée JM, Couch FJ, Couper D, Coveillo AD, Cox A, Czene K, D'adamo AP, Smith GD, De Vivo I, Demerath EW, Dennis J, Devilee P, Dieffenbach AK, Dunning AM, Eiriksdottir G, Eriksson JG, Fasching PA, Ferrucci L, Flesch-Janys D, Flyger H, Foroud T, Franke L, Garcia ME, García-Closas M, Geller F, de Geus EE, Giles GG, Gudbjartsson DF, Gudnason V, Guénel P, Guo S, Hall P, Hamann U, Haring R, Hartman CA, Heath AC, Hofman A, Hooning MJ, Hopper JL, Hu FB, Hunter DJ, Karasik D, Kiel DP, Knight JA, Kosma VM, Kutalik Z, Lai S, Lambrechts D, Lindblom A, Mägi R, Magnusson PK, Mannermaa A, Martin NG, Masson G, McArdle PF, McArdle WL, Melbye M, Michailidou K, Mihailov E, Milani L, Milne RL, Nevanlinna H, Neven P, Nohr EA, Oldehinkel AJ, Oostra BA, Palotie A, Peacock M, Pedersen NL, Peterlongo P, Peto J, Pharoah PD, Postma DS, Pouta A, Pylkäs K, Radice P, Ring S, Rivadeneira F, Robino A, Rose LM, Rudolph A, Salomaa V, Sanna S, Schlessinger D, Schmidt MK, Southey MC, Sovio U, Stampfer MJ, Stöckl D, Storniolo AM, Timpson NJ, Tyrer J, Visser JA, Vollenweider P, Völzke H, Waeber G, Waldenberger M, Wallaschofski H, Wang Q, Willemsen G, Winqvist R, Wolffenbuttel BH, Wright MJ, Boomsma DI, Econs MJ, Khaw KT, Loos RJ, McCarthy MI, Montgomery GW, Rice JP, Streeten EA, Thorsteinsdottir U, van Duijn CM, Alizadeh BZ, Bergmann S, Boerwinkle E, Boyd HA, Crisponi L, Gasparini P, Gieger C, Harris TB, Ingelsson E, Järvelin MR, Kraft P, Lawlor D, Metspalu A, Pennell CE, Ridker PM, Snieder H, Sørensen TI, Spector TD, Strachan DP, Uitterlinden AG, Wareham NJ, Widen E, Zygmunt M, Murray A, Easton DF, Stefansson K, Murabito JM, Ong KK

Australian Ovarian Cancer Study · GENICA Network · kConFab · LifeLines Cohort Study · InterAct Consortium · Early Growth Genetics (EGG) Consortium

Nature · 2014 · PMID 25231870 · open access

What people read about alongside this

Blood sugar and insulin1 Heart and circulation1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1469039

What is rs1469039?

rs1469039 is a single position in the genome, in or near the KCNK9 gene. Published research associates it with menarche (age at onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1469039 linked to?

On MyGeneLog this position is linked to Age at Menarche. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1469039?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1469039 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1469039 come from?

GWAS Catalog, Nature 2014, PMID:25231870. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Menarche (age at onset) (rs1469039). MyGeneLog™. https://www.mygenelog.com/variants/rs1469039

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