Standard
LDL cholesterol
LPA · rs186696265
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of LDL cholesterol — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with LDL cholesterol.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of LDL cholesterol compared to the general population.
Source
The impact of low-frequency and rare variants on lipid levels
Surakka I,
Horikoshi M,
Mägi R,
Sarin AP,
Mahajan A,
Lagou V,
Marullo L,
Ferreira T,
Miraglio B,
Timonen S,
Kettunen J,
Pirinen M
and 74 more — show all
Karjalainen J,
Thorleifsson G,
Hägg S,
Hottenga JJ,
Isaacs A,
Ladenvall C,
Beekman M,
Esko T,
Ried JS,
Nelson CP,
Willenborg C,
Gustafsson S,
Westra HJ,
Blades M,
de Craen AJ,
de Geus EJ,
Deelen J,
Grallert H,
Hamsten A,
Havulinna AS,
Hengstenberg C,
Houwing-Duistermaat JJ,
Hyppönen E,
Karssen LC,
Lehtimäki T,
Lyssenko V,
Magnusson PK,
Mihailov E,
Müller-Nurasyid M,
Mpindi JP,
Pedersen NL,
Penninx BW,
Perola M,
Pers TH,
Peters A,
Rung J,
Smit JH,
Steinthorsdottir V,
Tobin MD,
Tsernikova N,
van Leeuwen EM,
Viikari JS,
Willems SM,
Willemsen G,
Schunkert H,
Erdmann J,
Samani NJ,
Kaprio J,
Lind L,
Gieger C,
Metspalu A,
Slagboom PE,
Groop L,
van Duijn CM,
Eriksson JG,
Jula A,
Salomaa V,
Boomsma DI,
Power C,
Raitakari OT,
Ingelsson E,
Järvelin MR,
Thorsteinsdottir U,
Franke L,
Ikonen E,
Kallioniemi O,
Pietiäinen V,
Lindgren CM,
Stefansson K,
Palotie A,
McCarthy MI,
Morris AP,
Prokopenko I,
Ripatti S
Nature genetics · 2015 · PMID 25961943
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs186696265
What is rs186696265?
rs186696265 is a single position in the genome, in or near the LPA gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs186696265?
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs186696265 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs186696265 come from?
GWAS Catalog, Nat Genet 2015, PMID:25961943. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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