Standard

LDL cholesterol

LPA · rs186696265

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs186696265 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition Topic: Heart and circulation Heart and circulation Topic rs186696265 rs186696265 LPA

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied up 62,166 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.262 s.d. higher (95% confidence interval 0.19-0.33); p = 4 × 10−14.

How common The T allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 6, band 6q26 — between genes, 11.4 kb from PLG.

What each result means

C/C No copy of the version the research linked to LDL cholesterol. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to LDL cholesterol. That is a smaller link than two copies.
T/T Two copies of the version the research linked to LDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs186696265

What is rs186696265?

rs186696265 is a single position in the genome, in or near the LPA gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs186696265 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs186696265?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs186696265 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs186696265 come from?

GWAS Catalog, Nat Genet 2015, PMID:25961943. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

LDL cholesterol (rs186696265). MyGeneLog™. https://www.mygenelog.com/variants/rs186696265

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