EDN1 · rs5370
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,444 European ancestry individuals; replicated in 3,230 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 2.96 pmol/l higher (95% confidence interval 2.42-3.49); p = 1 × 10−27.
How common The T allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 6, band 6p24.1 — a missense change in EDN1.
What ClinVar records
Classification
Benign for High density lipoprotein cholesterol level quantitative trait locus 7, Auriculocondylar syndrome 3; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-02-01.
ClinVar record 16652 NM_001955.5(EDN1):c.594G>T (p.Lys198Asn)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs5370 is a single position in the genome, in or near the EDN1 gene. Published research associates it with circulating vasoactive peptide levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (5 papers), heart and circulation (4 papers), exercise and muscle (2 papers), liver (1 papers), sleep and insomnia (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hypertension 2013, PMID:23381795. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Circulating vasoactive peptide levels (rs5370). MyGeneLog™. https://www.mygenelog.com/variants/rs5370