Standard

CYP2C19 *17 — increased enzyme activity

CYP2C19 · rs12248560

Where this position leads

Drug: Clopidogrel

rs12248560 Drug: Clopidogrel Clopidogrel Drug rs12248560 rs12248560 CYP2C19

What each result means

C/C No copy of *17.
C/T One copy of CYP2C19*17, a promoter variant associated with increased enzyme activity rather than less. It sits on the other side of the same dial: more activation of prodrugs such as clopidogrel, and faster clearance of drugs the enzyme inactivates.
T/T Two copies of CYP2C19*17 — the ultrarapid end of the range. Guidelines treat this as normal-to-increased for clopidogrel; where it matters more is for drugs CYP2C19 breaks down rather than switches on.
This is a pharmacogenomic result with a published dosing guideline behind it. Tell a prescriber or pharmacist rather than acting on it — and never stop or change a prescribed medicine on the strength of a genotype.

Source: CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update, Clinical Pharmacology & Therapeutics (PMID 35034351).

Questions about rs12248560

What is rs12248560?

rs12248560 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with cyp2c19 *17 — increased enzyme activity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs12248560 affect how medicines work?

CYP2C19 carries pharmacogenomic findings for Clopidogrel. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs12248560 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12248560 come from?

CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update, Clinical Pharmacology & Therapeutics (PMID 35034351). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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