APOB · rs693
Where this position leads
Condition: Cholesterol (LDL, HDL and Total)
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 21,848 European ancestry individuals, 714 Orcadian individuals.
The effect Each copy of the G allele shifted the measure 0.1 s.d. lower; p = 9 × 10−23.
How common The G allele had a frequency of about 52% in the people studied.
Where it sits Chromosome 2, band 2p24.1 — a synonymous change in APOB.
What ClinVar records
Classification
Benign for Familial hypobetalipoproteinemia 1, Hypercholesterolemia, familial, 1, Warfarin response, Familial hypercholesterolemia, Hypercholesterolemia, autosomal dominant, type B and 1 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 18 submitters), last evaluated 2026-02-04.
ClinVar record 128425 NM_000384.3(APOB):c.7545C>T (p.Thr2515=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs693 is a single position in the genome, in or near the APOB gene. Published research associates it with cholesterol, total. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include cholesterol and blood fats (12 papers), heart and circulation (5 papers), blood sugar and insulin (5 papers), longevity and ageing (1 papers), alcohol and the flush (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2008, PMID:19060911. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cholesterol, total (rs693). MyGeneLog™. https://www.mygenelog.com/variants/rs693