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Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio)

ARID3B · rs2470893

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) — no copies of the reported risk allele. (GWAS Catalog, Hum Mol Genet 2016, PMID:27702941)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio). (GWAS Catalog, Hum Mol Genet 2016, PMID:27702941)
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) compared to the general population. (GWAS Catalog, Hum Mol Genet 2016, PMID:27702941)

Source: GWAS Catalog, Hum Mol Genet 2016, PMID:27702941

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2470893

What is rs2470893?

rs2470893 is a single position in the genome, in or near the ARID3B gene. Published research associates it with caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs2470893?

Subjects that appear in the title or abstract of the same papers as this rsID include caffeine and energy drinks (9 papers), blood sugar and insulin (3 papers), heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2470893 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2470893 come from?

GWAS Catalog, Hum Mol Genet 2016, PMID:27702941. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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