Sensitive

Coronary heart disease

RASD1 · rs12936587

Where this position leads

Condition: Coronary Artery Disease

rs12936587 Condition: Coronary Artery Disease Coronary Artery Disease Condition Topic: Heart and circulation Heart and circulation Topic rs12936587 rs12936587 RASD1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 22,233 European ancestry cases, 64,762 European ancestry controls; replicated in 56,682 European ancestry cases and controls.

The effect Each copy of the G allele carried 1.07 times the odds of Coronary heart disease (95% confidence interval 1.05-1.09); p = 4 × 10−10.

How common The G allele had a frequency of about 56% in the people studied.

Where it sits Chromosome 17, band 17p11.2 — between genes, 33.6 kb from SMCR2.

What each result means

A/A No copy of the version the research linked to Coronary heart disease. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Coronary heart disease. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Coronary heart disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs12936587

What is rs12936587?

rs12936587 is a single position in the genome, in or near the RASD1 gene. Published research associates it with coronary heart disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12936587 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs12936587?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (3 papers), blood sugar and insulin (1 papers), sleep and insomnia (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs12936587 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12936587 come from?

GWAS Catalog, Nat Genet 2011, PMID:21378990. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Coronary heart disease (rs12936587). MyGeneLog™. https://www.mygenelog.com/variants/rs12936587

← See all variants