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Who was studied 6,707 European ancestry cases, 52,426 European ancestry controls; replicated in 5,381 European ancestry casses, 10,030 European ancestry controls.
The effect
Each copy of the A allele carried 1.11 times the odds of Atrial fibrillation (95% confidence interval 1.08-1.15); p = 4 × 10−11.
How common The A allele had a frequency of about 42% in the people studied.
Where it sits Chromosome 9, band 9q22.32 — in an intron of AOPEP.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs10821415
What is rs10821415?
rs10821415 is a single position in the genome, in or near the C9orf3 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10821415 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs10821415?
Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs10821415 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10821415 come from?
GWAS Catalog, Nat Genet 2012, PMID:22544366. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 4932137223323Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity3Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others23Total49Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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