Sensitive

Coronary heart disease

ADAMTS7 · rs3825807

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 22,233 European ancestry cases, 64,762 European ancestry controls; replicated in 56,682 European ancestry cases and controls.

The effect Each copy of the A allele carried 1.08 times the odds of Coronary heart disease (95% confidence interval 1.06-1.10); p = 1 × 10⁻¹².

How common The A allele had a frequency of about 57% in the people studied.

Where it sits Chromosome 15, band 15q25.1 — a missense change in ADAMTS7.

What ClinVar records

Classification Benign for Three Vessel Coronary Disease; criteria provided, single submitter (1 of 4 stars, 2 submitters). ClinVar record 812638 NM_014272.5(ADAMTS7):c.640T>C (p.Ser214Pro)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Coronary heart disease. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Coronary heart disease. That is a smaller link than two copies.

G/G No copy of the version the research linked to Coronary heart disease. This is the starting point the study compared everyone against.

Source

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z

and 155 more — show all

Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, Mühleisen TW, Muhlestein JB, Münzel T, Musunuru K, Nahrstaedt J, Nelson CP, Nöthen MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Schäfer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WH, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JC, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, März W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J, Samani NJ

Cardiogenics · CARDIoGRAM Consortium

Nature genetics · 2011 · PMID 21378990

What people read about alongside this

Heart and circulation15 Blood sugar and insulin2

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs3825807

What is rs3825807?

rs3825807 is a single position in the genome, in or near the ADAMTS7 gene. Published research associates it with coronary heart disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3825807 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs3825807?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (15 papers), blood sugar and insulin (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs3825807 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3825807 come from?

GWAS Catalog, Nat Genet 2011, PMID:21378990. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Coronary heart disease (rs3825807). MyGeneLog™. https://www.mygenelog.com/variants/rs3825807

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