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Atrial fibrillation

KCNN3 · rs13376333

Where this position leads

Condition: Atrial Fibrillation

rs13376333 Condition: Atrial Fibrillation Atrial Fibrillation Condition Topic: Heart and circulation Heart and circulation Topic rs13376333 rs13376333 KCNN3

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 1,335 European ancestry cases, 12,844 European ancestry controls; replicated in 1,164 European ancestry cases, 3,607 European ancestry controls.

The effect Each copy of the T allele carried 1.52 times the odds of Atrial fibrillation (95% confidence interval 1.40-1.64); p = 2 × 10−21.

How common The T allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 1, band 1q21.3 — in an intron of KCNN3.

What each result means

C/C No copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs13376333

What is rs13376333?

rs13376333 is a single position in the genome, in or near the KCNN3 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13376333 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs13376333?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (16 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs13376333 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13376333 come from?

GWAS Catalog, Nat Genet 2010, PMID:20173747. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (rs13376333). MyGeneLog™. https://www.mygenelog.com/variants/rs13376333

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