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Serum thyroid-stimulating hormone levels

XKR4 · rs2622590

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,346 Han Chinese ancestry individuals; replicated in 3,235 She Chinese ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.03 lower; p = 2 × 10⁻¹⁰.

How common The A allele had a frequency of about 44% in the people studied.

Where it sits Chromosome 8, band 8q12.1 — in an intron of XKR4.

What each result means

A/A Two copies of the version the research linked to Serum thyroid-stimulating hormone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Serum thyroid-stimulating hormone levels. That is a smaller link than two copies.

G/G No copy of the version the research linked to Serum thyroid-stimulating hormone levels. This is the starting point the study compared everyone against.

Source

Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations

Zhan M, Chen G, Pan CM, Gu ZH, Zhao SX, Liu W, Wang HN, Ye XP, Xie HJ, Yu SS, Liang J, Gao GQ

and 9 more — show all

Yuan GY, Zhang XM, Zuo CL, Su B, Huang W, Ning G, Chen SJ, Chen JL, Song HD

China Consortium for Genetics of Autoimmune Thyroid Disease

Human molecular genetics · 2014 · PMID 24852370

What people read about alongside this

Heart and circulation1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2622590

What is rs2622590?

rs2622590 is a single position in the genome, in or near the XKR4 gene. Published research associates it with serum thyroid-stimulating hormone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs2622590?

Subjects that appear in the title or abstract of the same papers as this rsID include heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2622590 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2622590 come from?

GWAS Catalog, Hum Mol Genet 2014, PMID:24852370. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Serum thyroid-stimulating hormone levels (rs2622590). MyGeneLog™. https://www.mygenelog.com/variants/rs2622590

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