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Calcium levels

CASR · rs17251221

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 20,611 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.06 higher (95% confidence interval 0.05-0.07); p = 2 × 10⁻²².

How common The G allele had a frequency of about 14% in the people studied.

Where it sits Chromosome 3, band 3q21.1 — in an intron of CASR.

What each result means

A/A No copy of the version the research linked to Calcium levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Calcium levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Calcium levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels

O'Seaghdha CM, Yang Q, Glazer NL, Leak TS, Dehghan A, Smith AV, Kao WH, Lohman K, Hwang SJ, Johnson AD, Hofman A, Uitterlinden AG

and 12 more — show all

Chen YD, Brown EM, Siscovick DS, Harris TB, Psaty BM, Coresh J, Gudnason V, Witteman JC, Liu YM, Kestenbaum BR, Fox CS, Köttgen A

GEFOS Consortium

Human molecular genetics · 2010 · PMID 20705733

What people read about alongside this

Blood sugar and insulin1 Bones and fractures1 Heart and circulation1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs17251221

What is rs17251221?

rs17251221 is a single position in the genome, in or near the CASR gene. Published research associates it with calcium levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs17251221?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), bones and fractures (1 papers), heart and circulation (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs17251221 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17251221 come from?

GWAS Catalog, Hum Mol Genet 2010, PMID:20705733. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Calcium levels (rs17251221). MyGeneLog™. https://www.mygenelog.com/variants/rs17251221

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